125316-60-1
CD437
CAS: 125316-60-1
Molecular Formula: C27H26O3
125316-60-1 - Names and Identifiers
125316-60-1 - Physico-chemical Properties
| Molecular Formula | C27H26O3 |
| Molar Mass | 398.49 |
| Density | 1.290 |
| Melting Point | 271.6-276°C |
| Boling Point | 595.0±50.0 °C(Predicted) |
| Solubility | DMSO: 26mg/mL |
| Appearance | solid |
| Color | yellow |
| pKa | 4.17±0.30(Predicted) |
| Storage Condition | -20°C |
| In vitro study | CD437 is a selective RARγ agonist. Growth inhibition by CD437 in these lung cancer cell lines is apparent after 2 days of treatment with 10 μM CD437. Dose-response experiments demonstrate that CD437 reduces the numbers of H460, SK-MES-1, A549, and H292 cells with 50% inhibitory values of approximately 0.5, 0.4, 3, and 0.85 μM, respectively. Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity. |
| In vivo study | Tumors in CD437-treated mice stop growing, an effect that becomes already statistically significant (P<0.01) at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroma edge in CD437-treated tumors. |
125316-60-1 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | QJ1975900 |
125316-60-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.509 ml | 12.547 ml | 25.095 ml |
| 5 mM | 0.502 ml | 2.509 ml | 5.019 ml |
| 10 mM | 0.251 ml | 1.255 ml | 2.509 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.502 ml |
Last Update：2024-01-02 23:10:35
125316-60-1 - Reference Information
| biological activity | CD437 is a selective Retinoic Acid Receptor gamma (RARγ) agonist. |
| Target | retinotic Acid Receptor gamma (RAR gamma) |
| in vitro study | CD437 is a selective RAR gamma agonist. Growth inhibition by CD437 in his lung cancer cell lines is significant after 2 days of treatment with 10 μm CD437, and H292 cells with 50% inhibitory values of approval 0.5, 0.4, 3, and 0.85 μM, respectively. Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity. |
| in vivo study | Tumors in CD437-treated mice stop growing, an effect that at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroke edge in CD437-treated tumors. |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: 6-(3-(adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid Request for quotationCAS: 125316-60-1
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: CD-437 Request for quotationCAS: 125316-60-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: CD437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: CD-437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AHPN Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CD437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: CD437 Visit Supplier Webpage Request for quotation
CAS: 125316-60-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 125316-60-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 6-(3-(adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid Request for quotationCAS: 125316-60-1
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: CD-437 Request for quotationCAS: 125316-60-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: CD437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: CD-437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AHPN Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CD437 Visit Supplier Webpage Request for quotationCAS: 125316-60-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: CD437 Visit Supplier Webpage Request for quotation
CAS: 125316-60-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 125316-60-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History