12584-58-6
Insulin from porcine pancreas
CAS: 12584-58-6
Molecular Formula: C256H381N65O76S6
12584-58-6 - Names and Identifiers
12584-58-6 - Physico-chemical Properties
| Molecular Formula | C256H381N65O76S6 |
| Molar Mass | 5777.54 |
| Solubility | It can be solubilized in dilute acetic or hydrochloric acid, pH 2-3. |
| Appearance | Morphological powder |
| Color | White to Off-White |
| Merck | 13,5003 |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| MDL | MFCD00131380 |
| Physical and Chemical Properties | Chemical properties white or white-like crystalline powder. Mp233 ℃ (decomposition). Soluble in dilute acid and alkali, insoluble in water, ethanol, chloroform and ether. Stable in weak acid solution, easy to destroy in alkaline solution or high temperature conditions. The solution is left-handed, and the isoelectric point is pH5.30-5.35. |
| Use | Biochemical research, hypoglycemic pancreatic hormone, for the treatment of diabetes and other diseases. Insulin is the only hormone in the body that lowers blood sugar, and it is also the only hormone that promotes the synthesis of glycogen, fat, and protein. The mechanism of action belongs to the receptor tyrosine kinase mechanism. |
12584-58-6 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | NM8895000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 2937120000 |
12584-58-6 - Reference
| Reference Show more | 1. Zhang Fengyan, Ma Pengkai, Wang Zheng, a man in a row, Sun jiassen, Sun coxiang. Synthesis of polyketal PCADK and Preparation and characterization of insulin microspheres [J]. Chinese Journal of new drugs, 2015,24(07):818-822 826. 2. Zhao Hongyu, Wang Yu, Liu Xinyu, etc. Effects of Polygonum cuspidatum extract on blood glucose and blood lipid in type 2 diabetic rats [J]. Chinese herbal medicines, 2016, 039(007):1647-1650. 3. Zhang, Yujie, et al. "High drug-loading gold nanoclusters for responsive glucose control in type 1 diabetes." Journal of Nanotechnology 17.1 (2019): 1-11. 4. Sun, Xiuhua, et al. "Creation of antifouling microarrays by photopolymerization of zwitterionic compounds for protein assay and cell patterning." Biosensors and Bioelectronics 102 (2018): 63-69.https://doi.org/10.1016/j.bios.2017.11.001 5. [IF=3.205] Dandan Lan et al."Preparation of a hydroxyethyl-based monolithic column and its application in the isolation of intact proteins from complex bio-samples."J Chromatogr B. 2019 Jan;1104:89 6. [IF=2.877] Tao Wu et al."Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats."Chronobiol Int. 2017;34(1):78-92 7. [IF=7.514] Chi Zhang et al."Identification of soybean peptides and their effect on the growth and metabolism of Limosilactobacillus reuteri LR08."Food Chem. 2022 Feb;369:130923 8. [IF=4.966] Yifan Wang et al."Intestinal microbiota contributes to altered glucose metabolism in simulated microgravity mouse model."Faseb J. 2019 Sep;33(9):10140-10151 9. [IF=4.451] Chi Zhang et al."Effects of soybean protein isolates and peptides on the growth and metabolism of Lactobacillus rhamnosus."J Funct Foods. 2021 Feb;77:104335 10. [IF=4.36] Pin Gong et al."Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway."J Ethnopharmacol. 2021 Dec;281:114558 11. [IF=4.286] Lei Du et al."Rat BAT xenotransplantation recovers the fertility and metabolic health of PCOS mice."J Endocrinol. 2021 Feb;248(2):249-264 12. [IF=2.72] Dan Shen et al.Effects of L-arabinose by hypoglycemic and modulating gut microbiome in a high-fat diet- and streptozotocin-induced mouse model of type 2 diabetes mellitus.J Food Biochem. 2021 Dec;45(12):e13991 13. [IF=6.05] Xing Wei et al."Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy."Front Cardiovasc Med. 2022; 9: 800185 14. [IF=5.787] Zhu Shenglong et al."Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells."Cell Mol Biol Lett. 2022 Dec;27(1):1-13 15. [IF=7.514] Wenya Jiao et al."Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol."Food Chem. 2022 Apr;374:131755 16. [IF=8.697] Li-Shan Yan et al."Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway."Metabolism. 2022 Apr;:155200 |
12584-58-6 - Introduction
It is almost insoluble in water, ethanol, chloroform or ether; it is soluble in mineral acid (inorganic acid) or alkaline hydroxide solution. Gender, isoelectric point pI5.35-5.45
Last Update：2022-10-16 17:41:08
12584-58-6 - Production method
Pig or bovine pancreas is processed by quick freezing, stirring, extraction, etc. to obtain insulin seed fibrils, which are centrifuged to form insulin fibers, and finally purified and dried.
Last Update：2024-04-10 22:29:15
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Featured ProductsSpot supply
Product Name: Insulin from porcine pancreas Visit Supplier Webpage Request for quotationCAS: 12584-58-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Insulin (Porcine) Request for quotationCAS: 12584-58-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Insulin (Porcine) Visit Supplier Webpage Request for quotationCAS: 12584-58-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Insulin (swine) Visit Supplier Webpage Request for quotationCAS: 12584-58-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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