1262412-13-4
1-Boc-3-amino-3-azetidinecarboxylic acid
CAS: 1262412-13-4
Molecular Formula: C9H16N2O4
1262412-13-4 - Names and Identifiers
1262412-13-4 - Physico-chemical Properties
| Molecular Formula | C9H16N2O4 |
| Molar Mass | 216.23 |
| Density | 1.291±0.06 g/cm3(Predicted) |
| Boling Point | 350.2±42.0 °C(Predicted) |
| pKa | 1.90±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
1262412-13-4 - Introduction
1-Boc-3-amino-3-azetidinic acid is a pharmaceutical intermediate with the following properties:
1. Appearance: colorless or white crystalline solid;
2. molecular formula: C14H20N2O4;
3. Molecular weight: 288.32g/mol;
4. melting point: 118-121 ℃;
5. solubility: soluble in most organic solvents, such as chloroform, methanol and dichloromethane.
1-Boc-3-amino-3-azetidinecarboxylic acid is mainly used in the synthesis of protecting groups and amino acids in organic synthesis.
Method:
1-Boc-3-amino-3-azetidinecarboxylic acid is generally synthesized by the following steps:
1.3-amino -3-azetidine carboxylic acid and Boc2O (tert-butoxycarbonyl chloride) are reacted in diethyl carbonate (Et2CO3) and dimethyl sulfoxide (DMSO) solvent to generate 1-Boc-3-amino-3-azetidine chloride;
2. 1-Boc-3-amino-3-azetidinoyl chloride was reacted with sodium hydride (NaH) in diethyl carbonate (Et2CO3) and methanol (MeOH) solvent to yield 1-Boc-3-amino-3-azetidinecarboxylic acid.
Safety Information:
1-Boc-3-amino-3-azetidinecarboxylic acid is a chemical and the following safety precautions should be taken:
1. avoid contact with skin and eyes, avoid inhalation of gas or solution;
2. use should wear personal protective equipment, such as gloves, goggles, etc;
3. storage should be sealed, away from the fire and oxidant.
1. Appearance: colorless or white crystalline solid;
2. molecular formula: C14H20N2O4;
3. Molecular weight: 288.32g/mol;
4. melting point: 118-121 ℃;
5. solubility: soluble in most organic solvents, such as chloroform, methanol and dichloromethane.
1-Boc-3-amino-3-azetidinecarboxylic acid is mainly used in the synthesis of protecting groups and amino acids in organic synthesis.
Method:
1-Boc-3-amino-3-azetidinecarboxylic acid is generally synthesized by the following steps:
1.3-amino -3-azetidine carboxylic acid and Boc2O (tert-butoxycarbonyl chloride) are reacted in diethyl carbonate (Et2CO3) and dimethyl sulfoxide (DMSO) solvent to generate 1-Boc-3-amino-3-azetidine chloride;
2. 1-Boc-3-amino-3-azetidinoyl chloride was reacted with sodium hydride (NaH) in diethyl carbonate (Et2CO3) and methanol (MeOH) solvent to yield 1-Boc-3-amino-3-azetidinecarboxylic acid.
Safety Information:
1-Boc-3-amino-3-azetidinecarboxylic acid is a chemical and the following safety precautions should be taken:
1. avoid contact with skin and eyes, avoid inhalation of gas or solution;
2. use should wear personal protective equipment, such as gloves, goggles, etc;
3. storage should be sealed, away from the fire and oxidant.
Last Update：2024-04-10 22:29:15
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