1268521-16-9
tert-butyl N-[(2S,3S)-1-chloro-2-hydroxy-5,5-dimethylhexan-3-yl]carbamate
CAS: 1268521-16-9
Molecular Formula: C13H26ClNO3
1268521-16-9 - Names and Identifiers
1268521-16-9 - Physico-chemical Properties
| Molecular Formula | C13H26ClNO3 |
| Molar Mass | 279.8 |
1268521-16-9 - Introduction
Properties of tert-butyl N-[(2S,3S)-1-chloro-2-hydroxy-5, 5-dimethyl-3-hexyl] carbamate (abbreviated as L-tert-butylhydroxycarboxylic acid chloride):
Appearance: colorless or yellowish liquid
Chemical formula: C12H24ClNO3
Molecular weight: 267.78g/mol
Boiling point: about 160 ℃
Density: about 1.05g/cm³
L-tert-butyl hydroxycarboxylic acid chloride is mainly suitable for chiral synthesis and can be used as an important chiral reagent. It can be used to prepare chiral alcohols, acids and ethers with pharmacological activity. It is also used as a catalyst and ligand in asymmetric catalytic reactions.
Preparation method: L-tert-butyl hydroxycarboxylic acid chloride can be obtained by N,N-dimethylformamide chlorination reaction. First, L-tert-butylhydroxycarboxylic acid is reacted with N,N-dimethylformamide to give an intermediate N-(2S,3S)-tert-butyl-2-amino-3-hexyl ester, which is then chlorinated by a chlorinating agent to give the target product.
Safety information: L-tert-butyl hydroxycarboxylic acid chloride is an organic compound that may be toxic to humans. During use, care should be taken to avoid contact with skin, eyes and respiratory tract. Wear appropriate protective equipment such as gloves, goggles and masks during operation. At the same time, it is necessary to operate in a well-ventilated place to avoid its steam inhalation. In case of contact, rinse immediately with plenty of water and seek medical help.
Appearance: colorless or yellowish liquid
Chemical formula: C12H24ClNO3
Molecular weight: 267.78g/mol
Boiling point: about 160 ℃
Density: about 1.05g/cm³
L-tert-butyl hydroxycarboxylic acid chloride is mainly suitable for chiral synthesis and can be used as an important chiral reagent. It can be used to prepare chiral alcohols, acids and ethers with pharmacological activity. It is also used as a catalyst and ligand in asymmetric catalytic reactions.
Preparation method: L-tert-butyl hydroxycarboxylic acid chloride can be obtained by N,N-dimethylformamide chlorination reaction. First, L-tert-butylhydroxycarboxylic acid is reacted with N,N-dimethylformamide to give an intermediate N-(2S,3S)-tert-butyl-2-amino-3-hexyl ester, which is then chlorinated by a chlorinating agent to give the target product.
Safety information: L-tert-butyl hydroxycarboxylic acid chloride is an organic compound that may be toxic to humans. During use, care should be taken to avoid contact with skin, eyes and respiratory tract. Wear appropriate protective equipment such as gloves, goggles and masks during operation. At the same time, it is necessary to operate in a well-ventilated place to avoid its steam inhalation. In case of contact, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-10 22:29:15
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