128455-63-0

128455-63-0 - Names and Identifiers

Name	5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
Synonyms	RARECHEM AL BO 1764 5-Chloro-1-methyl-3-(trifluoromethyl) 4-Carboxy-5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole 5-chloro-1-methyl-3-trifluoromethylpyrazole-4-carboxylic acid 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate 5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-3-(trifluoromethyl)-
CAS	128455-63-0
EINECS	671-543-4
InChI	InChI=1/C6H4ClF3N2O2/c1-12-4(7)2(5(13)14)3(11-12)6(8,9)10/h1H3,(H,13,14)/p-1

128455-63-0 - Physico-chemical Properties

Molecular Formula	C6H4ClF3N2O2
Molar Mass	228.56
Density	1.71±0.1 g/cm3(Predicted)
Melting Point	201 °C
Boling Point	284.4±40.0 °C(Predicted)
Flash Point	125.8°C
Vapor Presure	0.0014mmHg at 25°C
pKa	1.77±0.50(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

128455-63-0 - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Class	IRRITANT

128455-63-0 - Introduction

5-Chloro-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid, also known as CF3-Py-COOH, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 5-Chloro-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid is a white solid.
-Solubility: It can be dissolved in many organic solvents, such as methanol, ethyl acetate and dichloromethane. However, its solubility in water is relatively low.

Use:
-can be used as pharmaceutical intermediates: 5-chloro -1-methyl -3-trifluoromethyl -1H-pyrazole -4-carboxylic acid can be used as an important intermediate for the synthesis of antiviral, anti-tumor and anti-inflammatory drugs.
-for organic synthesis reaction: it can be used for a variety of reactions in organic synthesis, such as ammoniation reaction, ethanolamine reaction and etherification reaction.

Preparation Method:
-Usually, 5-chloro-1-methyl-3-trifluoromethyl-1H-pyrazole can be obtained by hydrogenation, oxidation, and further esterification of 5-chloro-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid.

Safety Information:
The specific risk of-5-chloro-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid has not been clearly reported, but as an organic compound, attention should be paid to its irritation to the skin, eyes and respiratory system.
-During use, appropriate personal protective measures must be taken, such as wearing protective glasses, gloves and protective masks.
-It should be stored in a dark, dry, well-ventilated place, away from fire and combustibles.

Last Update：2024-04-09 02:00:41