128694-63-3

128694-63-3 - Names and Identifiers

Name	2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Synonyms	EU-0083300 MLS000850704 SMR000456721 TimTec1_003188 2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid 2-methyl-5-(trifluoromethyl)-3-pyrazolecarboxylic acid 2-METHYL-5-TRIFLUOROMETHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 1-Methyl-3-trifluoromethyl-1H-pyrazole-5-carboxylic acid Pyrazole-5-carboxylic acid, 3-trifluorromethyl-1-methyl- 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 1H-Pyrazole-5-carboxylic acid, 1-methyl-3-(trifluoromethyl)-
CAS	128694-63-3
EINECS	673-161-3
InChI	InChI=1/C6H5F3N2O2/c1-11-3(5(12)13)2-4(10-11)6(7,8)9/h2H,1H3,(H,12,13)

128694-63-3 - Physico-chemical Properties

Molecular Formula	C6H5F3N2O2
Molar Mass	194.11
Density	1.56±0.1 g/cm3(Predicted)
Melting Point	131-133℃
Boling Point	288.8±40.0 °C(Predicted)
Flash Point	128.4°C
Vapor Presure	0.00106mmHg at 25°C
pKa	2.55±0.25(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.497

128694-63-3 - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29331990
Hazard Class	IRRITANT

128694-63-3 - Reference Information

introduction

2-methyl -5 trifluoromethyl-2H-pyrazole -3-carboxylic acid is a derivative of pyrazole carboxylic acid, which has attracted more and more attention from researchers of pharmaceutical and chemical intermediates.

Preparation

2-methyl-5trifluoromethyl-2H-pyrazol-3-carboxylic acid is an intermediate for the synthesis of a drug for the treatment of cardiovascular diseases. It is reported that it is composed of diethyl oxalate and 2-pentanone through the condensation reaction of claisen esters, cyclization with hydrazine hydrate, methylation reaction, and hydrolysis reaction. The synthesis roadmap of 2-methyl -5 trifluoromethyl-2H-pyrazol-3-carboxylic acid is as follows:

Last Update：2024-04-09 02:00:06