13073-96-6
Decloxizine hydrochloride
CAS: 13073-96-6
Molecular Formula: C21H28N2O2.2ClH
13073-96-6 - Names and Identifiers
| Name | Decloxizine hydrochloride |
| Synonyms | Autokar Rescupal Decloxizine Hcl DECLOXIZINE DIHCL Hydroxydiethylphenamine Decloxizine hydrochloride Hydroxyzine EP Impurity B 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol,dihydrochloride 2-[2-[4-(DiphenylMethyl)-1-piperazinyl]ethoxy]ethanol Hydrochloride 2-(2-(4-(Diphenylmethyl)-1-piperazinyl)ethoxy)ethanol dihydrochloride 2-{2-[4-(diphenylmethyl)piperazin-1-yl]ethoxy}ethanol dihydrochloride Ethanol, 2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride 1-[2-(2-Hydroxyethoxy)ethyl]-4-α-phenylbenzyldiethylenediaMine Dihydrochloride 1-[2-(2-Hydroxyethoxy)ethyl]-4-alpha-phenylbenzyldiethylenediamine dihydrochloride |
| CAS | 13073-96-6 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C21H28N2O2.2ClH/c24-16-18-25-17-15-22-11-13-23(14-12-22)21(19-7-3-1-4-8-19)20-9-5-2-6-10-20;;/h1-10,21,24H,11-18H2;2*1H |
13073-96-6 - Physico-chemical Properties
| Molecular Formula | C21H28N2O2.2ClH |
| Molar Mass | 413.386 |
| Melting Point | 198 - 200°C |
| Boling Point | 472.4°C at 760 mmHg |
| Flash Point | 239.5°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 9.93E-10mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Use | Antiallergic drugs, mainly used in the treatment of bronchial asthma and asthmatic bronchitis |
13073-96-6 - Standard
Authoritative Data Verified Data
This product is 2-[2-[4-(diphenylmethyl)-l-piperazinyl] ethoxy] Ethanol dihydrochloride. Calculated as dry product, containing C21H28N202 • 2HC1 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
13073-96-6 - Trait
Authoritative Data Verified Data
- This product is white to yellowish powder; Odorless; With hygroscopicity.
- This product is very soluble in water, soluble in ethanol, slightly soluble in three gas methane, very slightly soluble in acetone, insoluble in ether.
Last Update：2022-01-01 14:20:49
13073-96-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.419 ml | 12.095 ml | 24.191 ml |
| 5 mM | 0.484 ml | 2.419 ml | 4.838 ml |
| 10 mM | 0.242 ml | 1.21 ml | 2.419 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.484 ml |
Last Update：2024-01-02 23:10:35
13073-96-6 - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, put it in a dry test tube, add malonic acid 30mg and acetic anhydride 0.5, and heat it to show red-brown color.
- take this product, add 0.1 mol/L hydrochloric acid solution was dissolved and diluted to prepare a solution containing about 10ug per 1 ml, and the maximum absorption was measured by ultraviolet-visible spectrophotometry (General 0401) at a wavelength of Nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 820).
- the aqueous solution of this product can identify the reaction of (1) (General rule 0301).
Last Update：2022-01-01 14:20:50
13073-96-6 - Exam
Authoritative Data Verified Data
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.8mg per 1 ml, as a test solution | Precision children take good 14, as a control solution, the mobile phase was diluted to the solution contained in 1 ml. According to the determination of high performance liquid chromatography (General 0512), with eighteen alkyl silane bonded silica gel as filler, methanol-water-triethylamine (42:58:0.5)(PH adjusted to 3.0 with phosphoric acid) as mobile phase, the detection wavelength was 225nm. The number of theoretical plates shall not be less than 4000 calculated by the peak of hydrochloric acid deschloroxazine, and the separation degree between the peak of hydrochloric acid deschloroxazine and the adjacent impurity peaks shall meet the requirements. 10 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 3.0% (General rule 0831).
ignition residue
not more than 0.15% (General rule 0841).
Heavy metals
take 0.50g of this product, add a little water to dissolve it, add 2ml of dilute acetic acid, dilute it with water to 25ml, and check it according to law (General rule 0821 first law), containing no more than 20 parts per million of heavy metals.
Last Update：2022-01-01 14:20:51
13073-96-6 - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add glacial acetic acid 15ml dissolved, add mercury acetate test solution 5ml and crystal violet indicator solution 1 drop, with high gas acid titration solution (O. 1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 20.67mg of C21H28N202 · 2HC1.
Last Update：2022-01-01 14:20:51
13073-96-6 - Category
Authoritative Data Verified Data
antihistamines.
Last Update：2022-01-01 14:20:51
13073-96-6 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 14:20:52
13073-96-6 - Deschlorhydroxyzine hydrochloride tablets
Authoritative Data Verified Data
This product contains hydrochloric acid chlorine hydroxyzine (C21H28N202 • 2HC1) should be 90.0% ~ 110.0% of the label.
trait
This product is sugar-coated tablets, White after removing the coating; Easy moisture absorption.
identification
- the sample solution under the content measurement item was taken and measured by ultraviolet-visible spectrophotometry (General 0401), and there was a maximum absorption at a wavelength of Nm.
- Take appropriate amount of fine powder of this product, add water, shake, filter, filtrate chloride to identify (1) reaction (General rule 0301).
examination
- Related substances take an appropriate amount of this product's fine powder (equivalent to 20mg of deschloroxazine hydrochloride), put it in a 25ml measuring flask, and add an appropriate amount of mobile phase, shake to dissolve deschloroxazine hydrochloride and dilute to scale with mobile phase, shake well, filter, and take filtrate as test solution; A solution containing 8ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. The test was carried out according to the method described under deschlorhydroxyzine hydrochloride related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity bee shall not be greater than 0.5 times (0.5%) of the area of the main peak of the control solution, the sum of the area of each impurity (B) shall not be greater than the area of the main peak of the control solution (1.0%).
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing take appropriate amount (about equivalent to hydrochloric acid chloro hydroxyzine 0.lg), put in a 100ml measuring flask, add 0.1 mol/L hydrochloric acid solution appropriate amount, shake to dissolve hydrochloric acid degassed hydroxyzine and use 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, take 2ml of continuous filtrate accurately, put it in a 100ml measuring flask, use 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, as the test solution, according to UV-visible spectrophotometry (General 0401), at the wavelength of 224nm absorbance; take another hydrochloric acid to the chlorine hydroxyzine control, precision weighing, add 0.lmol/L hydrochloric acid solution is dissolved and quantitatively diluted to make a solution containing about 20ug per lml, which is determined and calculated by the same method.
category
Same as deschloroxazine hydrochloride.
specification
(l)25mg (2)50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:20:52
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Mobile: +86-18621343501
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tech@medchemexpress.com
Mobile: 609-228-6898
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CAS: 13073-96-6
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View History
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