134029-62-2
3,4,5,4'-Tetramethoxystilbene
CAS: 134029-62-2
Molecular Formula: C18H20O4
134029-62-2 - Names and Identifiers
| Name | 3,4,5,4'-Tetramethoxystilbene |
| Synonyms | DMU212 DMU 212 DMU-212 3,4,5,4'-Tetramethoxystilbene 3,4,5,4'-TETRAMETHOXYSTILBENE (E)-3,4,5,4′-Tetramethoxystilbene 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene 1,2,3-Trimethoxy-5-[(E)-2-(4-methoxyphenyl)vinyl]benzene (E)-1,2,3-Trimethoxy-5-[2-(4-methoxyphenyl)ethenyl]benzene 1,2,3-trimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene 1,2,3-Trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene benzene, 1,2,3-trimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]- Benzene, 1,2,3-trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]- |
| CAS | 134029-62-2 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C18H20O4/c1-19-15-9-7-13(8-10-15)5-6-14-11-16(20-2)18(22-4)17(12-14)21-3/h5-12H,1-4H3/b6-5+ |
134029-62-2 - Physico-chemical Properties
| Molecular Formula | C18H20O4 |
| Molar Mass | 300.349 |
| Density | 1.117 |
| Melting Point | 157-159℃ |
| Boling Point | 444.0±40.0 °C(Predicted) |
| Flash Point | 144.057°C |
| Solubility | DMSO |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Refractive Index | 1.588 |
| Use | DMU-212 is a methylated derivative of resveratrol (HY-16561), which has anti-division, anti-proliferation, anti-oxidation and apoptosis-promoting activities. DMU-212 lead to mitotic arrest by inducing apoptosis (apoptosis) and activating ERK1/2 protein. DMU-212 have oral activity. |
134029-62-2 - Risk and Safety
| WGK Germany | 3 |
134029-62-2 - Reference
| Reference Show more | 1. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24(8):632-4.2. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68(4):397-400. |
134029-62-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.329 ml | 16.647 ml | 33.295 ml |
| 5 mM | 0.666 ml | 3.329 ml | 6.659 ml |
| 10 mM | 0.333 ml | 1.665 ml | 3.329 ml |
| 5 mM | 0.067 ml | 0.333 ml | 0.666 ml |
Last Update：2024-01-02 23:10:35
134029-62-2 - Reference Information
| biological activity | DMU-212 is a resveratrol (HY-16561) methylated derivative with anti-division, anti-proliferation, anti-oxidation and promoting cell apoptosis activity. DMU-212 lead to mitotic arrest by inducing apoptosis (apoptosis) and activating ERK1/2 protein. DMU-212 have oral activity. |
| Cell Line: | A375 cells, MeWo cells, M5 cells, Bro cells A375 cells A375 cells |
| Concentration: | 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM 20 μM, 30 μM, 50 μM 20 μM, 30 μM, 50 μM |
| Incubation Time: | 96 hours 24 hours 24 hours |
| Result: | Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. Lower tumor burden. |
| Animal Model: | 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage, three times a week, for 14 days |
Last Update：2024-04-09 21:04:16
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