135729-61-2
Palonosetron
CAS: 135729-61-2
Molecular Formula: C19H24N2O
135729-61-2 - Names and Identifiers
135729-61-2 - Physico-chemical Properties
| Molecular Formula | C19H24N2O |
| Molar Mass | 296.41 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Melting Point | 87-88° |
| Boling Point | 470.4±45.0 °C(Predicted) |
| Specific Rotation(α) | D -136° (c = 0.25 in chloroform) |
| pKa | 9.77±0.33(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Palonosetron is a 5-HT3 receptor antagonist with a high binding affinity for this receptor and only very weak or no binding affinity for other receptors. |
| In vivo study | Palonosetron has a longer half-life and higher binding affinity than first generation 5-HT3 receptor antagonists. After administration of intravenous injections to healthy volunteers and cancer patients, the blood concentration of palonosetron decreased from the initial to the later slow elimination from the body. The mean maximum plasma concentration and the area under the concentration-time curve are generally dose proportional (linear) over the 0.3-90 μg/kg dose range. Palonosetron has a volume of distribution of about 8.3±2.5 L/kg and a binding rate to plasma proteins of 62%. It is mainly eliminated from the body through renal excretion and metabolic pathways, and the average terminal elimination half-life is about 40 hours. |
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View History
135729-61-2
15068-35-6
53792-97-5
21900-39-0
210282-31-8
6942-99-0
18586-22-6
87981-13-3
1996-30-1
115562-53-3
15068-35-6
53792-97-5
21900-39-0
210282-31-8
6942-99-0
18586-22-6
87981-13-3
1996-30-1
115562-53-3