136164-66-4
(E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid
CAS: 136164-66-4
Molecular Formula: C21H30O6
136164-66-4 - Names and Identifiers
136164-66-4 - Physico-chemical Properties
| Molecular Formula | C21H30O6 |
| Molar Mass | 378.46 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Melting Point | 56-57 °C |
| Boling Point | 542.2±50.0 °C(Predicted) |
| Solubility | DMSO: >20mg/mL |
| Appearance | powder |
| Color | red to orange |
| pKa | 4.29±0.19(Predicted) |
| Storage Condition | 2-8°C |
| Use | E3330 is a potent and selective inhibitor of AP endonuclease 1 redox domain.E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration. E3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines. E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis. |
| Target | Ape-1, Ref-1 |
| In vitro study | In vitro, E3330 affects hemangioblast development by inhibiting Ape1 redox activity. E3330 inhibits the growth of human pancreatic cancer cell lines PANC1,XPA1,MIAPACA,BxPC3, and pk9. In PANC1 cells, E3330 also promotes the end of the cell cycle, inhibits the DNA binding activity of HIF-1α and the migration of pancreatic cancer cells. In adhh6 cells, E3330 prevents the functional activity of NF-κB by altering the Subcellular transport of APE1 and by blocking the redox-mediated activation of NF-κB, decreased TNF-α and FAs accumulation induced expression by IL-6 and IL-8. |
| In vivo study | In mice with endotoxin-mediated hepatitis, E3330 (300 mg/kg, p.o.) attenuated the increase in plasma tumor necrosis factor activity and protected mice from liver injury. In a rat model, E3330 (100 mg/kg, p.o.) also protects rats from endotoxin and galactose-induced liver injury. |
136164-66-4 - Reference
| Reference Show more | 1: Cesaratto L, Codarin E, Vascotto C, Leonardi A, Kelley MR, Tiribelli C, Tell G. Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines. PLoS One. 2013 Aug 15;8(8):e70909. doi: 10.1371/journal.pone.0070909. eCollection 2013. PubMed PMID: 23967134; PubMed Central PMCID: PMC3744539. 2: Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF, Nyland RL 2nd, Gross ML, Georgiadis MM. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxid Redox Signal. 2011 Apr 15;14(8):1387-401. doi: 10.1089/ars.2010.3410. Epub 2011 Jan 4. PubMed PMID: 20874257; PubMed Central PMCID: PMC3061197. 3: Zou GM, Karikari C, Kabe Y, Handa H, Anders RA, Maitra A. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis. J Cell Physiol. 2009 Apr;219(1):209-18. doi: 10.1002/jcp.21666. PubMed PMID: 19097035. 4: Zou GM, Maitra A. Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther. 2008 Jul;7(7):2012-21. doi: 10.1158/1535-7163.MCT-08-0113. PubMed PMID: 18645011; PubMed Central PMCID: PMC3569736. 5: Saitou Y, Shiraki K, Yamanaka T, Miyashita K, Inoue T, Yamanaka Y, Yamaguchi Y, Enokimura N, Yamamoto N, Itou K, Sugimoto K, Nakano T. Augmentat |
136164-66-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.642 ml | 13.211 ml | 26.423 ml |
| 5 mM | 0.528 ml | 2.642 ml | 5.285 ml |
| 10 mM | 0.264 ml | 1.321 ml | 2.642 ml |
| 5 mM | 0.053 ml | 0.264 ml | 0.528 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: E3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (E)-2-((4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoicacid Request for quotationCAS: 136164-66-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: E3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: APX-3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid Visit Supplier Webpage Request for quotation
CAS: 136164-66-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 136164-66-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: E3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (E)-2-((4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoicacid Request for quotationCAS: 136164-66-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: E3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: APX-3330 Visit Supplier Webpage Request for quotationCAS: 136164-66-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid Visit Supplier Webpage Request for quotation
CAS: 136164-66-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 136164-66-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
136164-66-4
481634-76-8
1477-68-5
2-ethvlhexvlpalmitate
P-PHENYLCINNAMIC ACID
SODIUM TRICHLOROPHENATE
氢化钛
SILICICACID,DISODIUMSALT,PENTAHYDRATE
Benzyloxyacetaldehyde
DS-36
481634-76-8
1477-68-5
2-ethvlhexvlpalmitate
P-PHENYLCINNAMIC ACID
SODIUM TRICHLOROPHENATE
氢化钛
SILICICACID,DISODIUMSALT,PENTAHYDRATE
Benzyloxyacetaldehyde
DS-36