13623-87-5
1,2,3,4-Tetrahydro-1,8-Naphthyridine
CAS: 13623-87-5
Molecular Formula: C8H10N2
13623-87-5 - Names and Identifiers
13623-87-5 - Physico-chemical Properties
| Molecular Formula | C8H10N2 |
| Molar Mass | 134.18 |
| Density | 1.18±0.1 g/cm3(Predicted) |
| Boling Point | 96 °C(Press: 0.6 Torr) |
| pKa | 10.81±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
13623-87-5 - Reference Information
| Application | 1,2,3,4-tetrahydro-1, 8-naphthalene is an organic intermediate that can be obtained by reducing 1,8-naphthalene with hydrogen. 1,2,3, 4-tetrahydro-1, 8-naphthyridine can be used to prepare (E)-3-(5,6,7, 8-tetrahydro-1, 8-naphthyridine -3-base) acrylic acid. This class of compounds is a Fab I inhibitor and has antibacterial activity. Therefore, it can be used to treat bacterial infections in mammals, especially humans. |
| preparation | in a glove box filled with argon, add potassium tert-butoxide (5.6mg,0.05mmol), manganese catalyst (0.005mmol), tetrahydrofuran (0.5mL) and 1,8-naphthyridine (0.25mmol) to a 4mL glass bottle with a stirrer, and cover the bottle, A needle with a vent hole (length 3cm, the aperture of the vent hole is 1mm) is inserted into the bottle cap, the glass bottle is put into the autoclave, then the autoclave is taken out from the glove box, argon gas (3 × 10bar) in the autoclave is replaced with hydrogen gas, then 80bar hydrogen is filled, and the reaction is 16h at 120 ℃; After the reaction is over, the ice water bath is cooled, and the gas in the autoclave is carefully released, the obtained reaction product system was sampled for GC quantification and separated by column chromatography to obtain the target product. |
Last Update：2024-04-09 02:00:01
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