136552-06-2

136552-06-2 - Names and Identifiers

Name	(S)-N-Fmoc-Azetidine-2-carboxylic acid
Synonyms	RARECHEM EM WB 0078 (S)-N-FMOC-AZETIDINE-2-CARBOXYLIC ACID (S)-N-Fmoc-Azetidine-2-carboxylic acid 1-Fmoc-(S)-azetidine-2-carboxylic acid N-ALPHA-FMOC-L-AZETIDINE-2-CARBOXYLIC ACID (S)-N-(9-FLUORENYLMETHOXYCARBONYL)-AZETIDINE-2-CARBOXYLIC ACID (S)-N-(9-Fluorenylmethoxycarbonyl)-azetidine-2-carboxylic acid (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylate N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDINE-2-CARBOXYLIC ACID N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-AZETIDENE-2-CARBOXYLIC ACID (S)-AZETIDINE-1,2-DICARBOXYLIC ACID 1-(9H-FLUOREN-9-YLMETHYL) ESTER (2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-2-carboxylic acid
CAS	136552-06-2
InChI	InChI=1/C19H17NO4/c21-18(22)17-9-10-20(17)19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,22)/p-1/t17-/m0/s1
InChIKey	BXRZCDISGRVJCA-KRWDZBQOSA-N

136552-06-2 - Physico-chemical Properties

Molecular Formula	C19H17NO4
Molar Mass	323.34
Density	1.2675 (rough estimate)
Melting Point	135 °C
Boling Point	461.82°C (rough estimate)
Flash Point	282.3°C
Vapor Presure	1.24E-12mmHg at 25°C
Appearance	Powder
Color	White to light yellow
pKa	3.95±0.20(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.5000 (estimate)

136552-06-2 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29223990
Hazard Class	IRRITANT

136552-06-2 - Introduction

1-Fmoc-(S)-azetidine-2-carboxylic acid is an organic compound with the following properties:

Nature:
-Appearance: White solid
-Molecular formula: C25H21NO4
-Molecular weight: 395.44g/mol
-melting point: 165-170 ℃

Use:
1-Fmoc-(S)-azetidine-2-carboxylic acid is commonly used in protecting groups and intermediates in organic synthesis. It is mainly used as a method of amino protecting group in peptide synthesis, which can prevent non-specific reaction and side reaction. By controlling the protection and deprotection reactions of the amino group, a highly pure peptide sequence can be efficiently synthesized.

Preparation Method:
The preparation of 1-Fmoc-(S)-azetidine-2-carboxylic acid is generally accomplished by chemical reaction. A specific synthetic method may be the use of azetidine and phenyl difluoromethylmethyl ester to produce 1-Fmoc-(S)-azetidine-2-carboxylic acid.

Safety Information:
1-Fmoc-(S)-azetidine-2-carboxylic acid is a chemical, and safety measures should be taken when using it:
-Avoid inhalation or contact with skin and eyes. If contact occurs, rinse immediately with plenty of water.
-Appropriate personal protective equipment should be worn, including lab gloves, goggles, and lab coats.
-In operation, to maintain a good ventilation system or laboratory exhaust operation.
-should be stored away from fire and oxidant, in a dry, cool place, avoid direct sunlight.
-All handling and disposal shall comply with local codes and regulations.

Last Update：2024-04-10 22:29:15