137654-21-8
2-Fluoro-6-Methoxybenzoic Acid
CAS: 137654-21-8
Molecular Formula: C8H7FO3
137654-21-8 - Names and Identifiers
| Name | 2-Fluoro-6-Methoxybenzoic Acid |
| Synonyms | RARECHEM AL BO 0442 6-Fluoro-o-anisic acid 6-Fluoro-2-methoxybenzoic acid 2-Fluoro-6-Methoxybenzoic Acid 2-FLUORO-6-METHOXYBENZOIC ACID Benzoic acid,2-fluoro-6-methoxy- Benzoic acid, 2-fluoro-6-methoxy- 2-chloro-1-fluoro-4-isothiocyanatobenzene 6-Fluoro-o-anisic acid, 2-Carboxy-3-fluoroanisole |
| CAS | 137654-21-8 |
| InChI | InChI=1/C8H7FO3/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4H,1H3,(H,10,11) |
137654-21-8 - Physico-chemical Properties
| Molecular Formula | C8H7FO3 |
| Molar Mass | 170.14 |
| Density | 1.307 |
| Melting Point | 89-93 °C (lit.) |
| Boling Point | 259℃ |
| Flash Point | 111℃ |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.00664mmHg at 25°C |
| Appearance | White to white-like powder or solid |
| Color | White to off-white |
| pKa | 3.16±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.524 |
| MDL | MFCD00671764 |
| Physical and Chemical Properties | Density: 1.31g/cm3 Melting Point: 89-93 ℃(lit.) Boiling Point: 279.7 ° Cat760mmHg flash point: 122.9 ℃ WGK Germany:3 |
137654-21-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29189900 |
| Hazard Class | IRRITANT |
137654-21-8 - Introduction
2-Fluoro-6-methoxybenzoic acid is an organic compound. Its chemical formula is C8H7FO3 and its molecular weight is 166.14.
Nature:
2-fluoro-6-methoxybenzoic acid is a solid and has a white to light yellow crystalline form at room temperature. It has low solubility in water, but better solubility in organic solvents. This compound is acidic and can react with a base to form the corresponding benzoate.
Use:
2-Fluoro-6-methoxybenzoic acid is commonly used as an intermediate and starting material for the synthesis of pharmaceuticals, pesticides and chemicals. It is used in the pharmaceutical industry for the synthesis of anti-inflammatory and anti-fungal drugs. In addition, it can also be used as a carboxylic acid protecting reagent in organic synthesis reactions.
Preparation Method:
There are many methods for preparing 2-fluoro-6-methoxybenzoic acid. The commonly used methods are obtained by reacting p-methoxybenzoic acid with hydrogen fluoride or by reducing and fluorinating p-methoxynitrobenzene.
Safety Information:
The toxicity of 2-fluoro-6-methoxybenzoic acid is low, but it is still necessary to pay attention to safe operation. Wear protective gloves, glasses and a mask to prevent contact and inhalation during use or handling. Avoid swallowing or touching it on the skin. In case of accidental use or contact with skin or eyes, rinse immediately with plenty of water and seek medical attention.
Nature:
2-fluoro-6-methoxybenzoic acid is a solid and has a white to light yellow crystalline form at room temperature. It has low solubility in water, but better solubility in organic solvents. This compound is acidic and can react with a base to form the corresponding benzoate.
Use:
2-Fluoro-6-methoxybenzoic acid is commonly used as an intermediate and starting material for the synthesis of pharmaceuticals, pesticides and chemicals. It is used in the pharmaceutical industry for the synthesis of anti-inflammatory and anti-fungal drugs. In addition, it can also be used as a carboxylic acid protecting reagent in organic synthesis reactions.
Preparation Method:
There are many methods for preparing 2-fluoro-6-methoxybenzoic acid. The commonly used methods are obtained by reacting p-methoxybenzoic acid with hydrogen fluoride or by reducing and fluorinating p-methoxynitrobenzene.
Safety Information:
The toxicity of 2-fluoro-6-methoxybenzoic acid is low, but it is still necessary to pay attention to safe operation. Wear protective gloves, glasses and a mask to prevent contact and inhalation during use or handling. Avoid swallowing or touching it on the skin. In case of accidental use or contact with skin or eyes, rinse immediately with plenty of water and seek medical attention.
Last Update：2024-04-09 20:52:54
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