140695-84-7
(S)-N-Boc-piperdine-3-hydroxymethyl
CAS: 140695-84-7
Molecular Formula: C11H21NO3
140695-84-7 - Names and Identifiers
140695-84-7 - Physico-chemical Properties
| Molecular Formula | C11H21NO3 |
| Molar Mass | 215.29 |
| Density | 1.059±0.06 g/cm3(Predicted) |
| Melting Point | 96-98 °C |
| Boling Point | 308.0±15.0 °C(Predicted) |
| Flash Point | 140.1°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 6.41E-05mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White |
| pKa | 14.93±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.479 |
| MDL | MFCD02683203 |
140695-84-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| HS Code | 29333990 |
140695-84-7 - Introduction
(S)-1-Boc-3-hydroxymethylpiperidine, chemical name (S)-3-Hydroxymethylpiperidine 1-benzyloxycarbonyl-(S)-3-Boc, is an organic compound.
Nature:
(S)-1-Boc-3-hydroxymethylpiperidine is a solid and has a bitter taste. Its molecular formula is C13H21NO3 and its relative molecular mass is 239.31. It has a melting point of 53-57°C and a boiling point of 347.4°C. It is stable at room temperature and can be dissolved in some organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
Use:
(S)-1-Boc-3-hydroxymethylpiperidine is an important intermediate in organic synthesis. It can be used in the preparation of bioactive molecules, drugs and pesticides and other compounds. It is often used as a catalyst for the synthesis of chiral chain ketones and as a precursor for chiral separating agents. In addition, it can be used to synthesize compounds such as peptides and fatty acids.
Preparation Method:
The preparation method of (S)-1-Boc-3-hydroxymethylpiperidine is relatively simple. A common method is obtained by reacting (S)-3-hydroxymethylpiperidine with 1-Boc-carbamate. The reaction is generally carried out under basic conditions, and organic solvents such as dimethyl sulfoxide or methylene chloride are commonly used.
Safety Information:
(S)-1-Boc-3-hydroxymethylpiperidine is relatively safe under general operation, but the following matters still need to be paid attention:
1. Avoid inhaling the vapor of dust or its solution, and wear appropriate protective equipment, such as gloves and goggles, during operation.
2. avoid contact with skin and eyes, if there is contact, should immediately rinse with plenty of water.
3. in storage and handling to prevent contact with oxidants and acids, to avoid dangerous chemical reactions or fire.
4. in the use and disposal, to follow the local safety regulations and operating procedures.
Nature:
(S)-1-Boc-3-hydroxymethylpiperidine is a solid and has a bitter taste. Its molecular formula is C13H21NO3 and its relative molecular mass is 239.31. It has a melting point of 53-57°C and a boiling point of 347.4°C. It is stable at room temperature and can be dissolved in some organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
Use:
(S)-1-Boc-3-hydroxymethylpiperidine is an important intermediate in organic synthesis. It can be used in the preparation of bioactive molecules, drugs and pesticides and other compounds. It is often used as a catalyst for the synthesis of chiral chain ketones and as a precursor for chiral separating agents. In addition, it can be used to synthesize compounds such as peptides and fatty acids.
Preparation Method:
The preparation method of (S)-1-Boc-3-hydroxymethylpiperidine is relatively simple. A common method is obtained by reacting (S)-3-hydroxymethylpiperidine with 1-Boc-carbamate. The reaction is generally carried out under basic conditions, and organic solvents such as dimethyl sulfoxide or methylene chloride are commonly used.
Safety Information:
(S)-1-Boc-3-hydroxymethylpiperidine is relatively safe under general operation, but the following matters still need to be paid attention:
1. Avoid inhaling the vapor of dust or its solution, and wear appropriate protective equipment, such as gloves and goggles, during operation.
2. avoid contact with skin and eyes, if there is contact, should immediately rinse with plenty of water.
3. in storage and handling to prevent contact with oxidants and acids, to avoid dangerous chemical reactions or fire.
4. in the use and disposal, to follow the local safety regulations and operating procedures.
Last Update：2024-04-09 20:52:54
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