1427-07-2
2-Fluoro-4-nitrotoluene
CAS: 1427-07-2
Molecular Formula: C7H6FNO2
1427-07-2 - Names and Identifiers
| Name | 2-Fluoro-4-nitrotoluene |
| Synonyms | 2-Fluoro-4-nitrotluene 4-Fluoro-4-Nitrotoluene 2-Fluoro-4-nitrotoluene 2-Fluoro-4-Nitrobenzene 2-FLUORO-4-NITROTOLUENE Toluene, 2-fluoro-4-nitro- 2-Fluor-1-methyl-4-nitrobenzol 2-FLUORO-1-METHYL-4-NITROBENZENE 2-Fluoro-1-methyl-4-nitrobenzene Benzene, 2-fluoro-1-methyl-4-nitro- |
| CAS | 1427-07-2 |
| EINECS | 215-845-2 |
| InChI | InChI=1/C7H6FNO2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,1H3 |
| InChIKey | WIQISTBTOQNVCE-UHFFFAOYSA-N |
1427-07-2 - Physico-chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molar Mass | 155.13 |
| Density | 1.3021 (estimate) |
| Melting Point | 31-35 °C (lit.) |
| Boling Point | 65-68 °C/2 mmHg (lit.) |
| Flash Point | 165°F |
| Water Solubility | Insoluble in water. Solubility in methanol gives very faint turbidity. |
| Vapor Presure | 0.124mmHg at 25°C |
| Appearance | Crystalline Low Melting Solid |
| Color | Yellow to brown |
| BRN | 2250156 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.53 |
| Physical and Chemical Properties | > |
| Use | For the synthesis of pharmaceuticals and pesticides |
1427-07-2 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 1325 4.1/PG 2 |
| WGK Germany | 3 |
| HS Code | 29049085 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
1427-07-2 - Reference Information
| freezing point | 32.0 to 35.0 ℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Introduction | 2-fluoro-4-nitrotoluene is an aromatic fluoride, aromatic fluorides are important intermediates for the synthesis of various functional fluorinated organic compounds, so their synthesis methods play an important role in the fields of medicine and materials. |
| Application | 2-fluoro-4-nitrotoluene is an intermediate in organic synthesis and pharmaceutical research and development, can be used in the laboratory of organic synthesis and chemical pharmaceutical synthesis process. |
| preparation method | preparation of 2-fluoro-4-nitrotoluene from 2, 4-dinitrotoluene: take choline chloride (0.14g,1mmol) and urea (0.12g,2mmol) to prepare eutectic, add 2, 4-dinitrotoluene (2mmol), potassium fluoride (15mmol) and DMSO(2.5ml), heated to 160 °c, and reacted for 8 hours. The temperature was cooled to room temperature, 10ml of water was added, and the mixture was sufficiently stirred. Ethyl acetate (10ml × 3) was added to extract the aqueous layer, and the organic layer was combined, and the organic layer was washed with saturated brine (10ml × 3). MgSO4 was dried and the crude product was obtained by rotary evaporation. The product was separated by column chromatography to obtain 2-fluoro-4-nitrotoluene. |
| Use | for the synthesis of medicines and pesticides |
Last Update：2024-04-09 02:00:04
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