143591-61-1
3-bromo-8-chloroimidazo[1,2-a]pyrazine
CAS: 143591-61-1
Molecular Formula: C6H3BrClN3
143591-61-1 - Names and Identifiers
| Name | 3-bromo-8-chloroimidazo[1,2-a]pyrazine |
| Synonyms | 8-Chloro-3-bromoimidazo[1,2-a]pyrazine 3-Bromo-8-chloroimidazo[1,2-a]pyrazine 3-bromo-8-chloroimidazo[1,2-a]pyrazine 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE imidazo[1,2-a]pyrazine, 3-bromo-8-chloro- Imidazo[1,2-a]pyrazine, 3-bromo-8-chloro- |
| CAS | 143591-61-1 |
| InChI | InChI=1/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H |
143591-61-1 - Physico-chemical Properties
| Molecular Formula | C6H3BrClN3 |
| Molar Mass | 232.47 |
| Density | 2.03±0.1 g/cm3(Predicted) |
| pKa | -1.45±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.768 |
143591-61-1 - Introduction
3-bromo-8-chloroimidazo[1,2-a]pyrazine is an imidazo[1,2-a]pyrazine compound containing bromine and chlorine atoms. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3-bromo-8-chrooimidazo [1,2-a]pyrazine is a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as chloroform, dimethyl sulfoxide, etc.
-Melting point: About 250-255 degrees Celsius.
Use:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine is commonly used as an intermediate and reagent in organic synthesis.
-The compound has certain biological activity in the field of medicine, and can be used to synthesize anti-tumor, anti-virus, antibacterial and other drugs.
Method:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine can be prepared by various methods. The common methods are as follows:
1. Reacting 4,5-dichloroimidazole with 2-bromoketone to obtain 3-bromo-4, 5-dichloroimidazole;
2.3-bromo-8-chloro imidazole [1,2-a]pyrazine was prepared by catalytic chlorination of 3-bromo -4,5-dichloro imidazole with acetone copper chloride.
Safety Information:
- 3-bromo-8-chloroimidazo[1,2-a]pyrazine has low safety and is an organic halogenated compound with certain toxicity and potential danger.
-Use should follow the laboratory's safe practices and be equipped with appropriate personal protective equipment, such as gloves, goggles, protective clothing, etc.
-Avoid direct contact of the compound with skin, eyes and respiratory tract.
-in the storage and handling process should pay attention to prevent its reaction with flammable substances, oxidants, etc.
Nature:
-Appearance: 3-bromo-8-chrooimidazo [1,2-a]pyrazine is a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as chloroform, dimethyl sulfoxide, etc.
-Melting point: About 250-255 degrees Celsius.
Use:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine is commonly used as an intermediate and reagent in organic synthesis.
-The compound has certain biological activity in the field of medicine, and can be used to synthesize anti-tumor, anti-virus, antibacterial and other drugs.
Method:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine can be prepared by various methods. The common methods are as follows:
1. Reacting 4,5-dichloroimidazole with 2-bromoketone to obtain 3-bromo-4, 5-dichloroimidazole;
2.3-bromo-8-chloro imidazole [1,2-a]pyrazine was prepared by catalytic chlorination of 3-bromo -4,5-dichloro imidazole with acetone copper chloride.
Safety Information:
- 3-bromo-8-chloroimidazo[1,2-a]pyrazine has low safety and is an organic halogenated compound with certain toxicity and potential danger.
-Use should follow the laboratory's safe practices and be equipped with appropriate personal protective equipment, such as gloves, goggles, protective clothing, etc.
-Avoid direct contact of the compound with skin, eyes and respiratory tract.
-in the storage and handling process should pay attention to prevent its reaction with flammable substances, oxidants, etc.
Last Update：2024-04-09 02:00:42
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