1445993-26-9
ABBV-075
CAS: 1445993-26-9
Molecular Formula: C22H19F2N3O4S
1445993-26-9 - Names and Identifiers
| Name | ABBV-075 |
| Synonyms | 5100 ABBV-075 Mivebresib Mivebresib (ABBV-075 ) N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide |
| CAS | 1445993-26-9 |
1445993-26-9 - Physico-chemical Properties
| Molecular Formula | C22H19F2N3O4S |
| Molar Mass | 459.4658 |
| Density | 1.465±0.06 g/cm3(Predicted) |
| Boling Point | 608.9±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 37 mg/mL |
| pKa | 8.37±0.10(Predicted) |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive Mivebresib (ABBV-075) is a new type of BET family bromodomain inhibitor. Binding to the bromine region of BRD2/4/T with similar affinity (Ki value between 1-2.2 nM) is highly selective. The efficacy for BRD3 is relatively low (Ki = 12.2 nM) and the activity for CREBBP is moderate (Ki = 87 μM). Mivebresib(ABBV-075) can effectively trigger apoptosis of various tumor cells. |
1445993-26-9 - Upstream Downstream Industry
1445993-26-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.176 ml | 10.882 ml | 21.764 ml |
| 5 mM | 0.435 ml | 2.176 ml | 4.353 ml |
| 10 mM | 0.218 ml | 1.088 ml | 2.176 ml |
| 5 mM | 0.044 ml | 0.218 ml | 0.435 ml |
Last Update：2024-01-02 23:10:35
1445993-26-9 - Uses and synthesis methods
Target
Target Value
BRD2
BRD4
BRD-T
in vitro studies
ABBV-075 has strong single drug activity in a variety of cancer cell lines (from solid tumors, leukemia and lymphoma) in cell viability testing. It can destroy cell cycle control, lead to G1 phase arrest, further aging, inhibit tumor formation, cause apoptosis, and may target tumor microenvironment to further provide better curative effect.
In vivo studies
In mouse models of lateral xenotransplantation of non-small cell and small cell lung cancer, pancreatic cancer, breast cancer, prostate cancer, head and neck cancer, multiple lymphoma, disseminated giant B- cell lymphoma and leukemia, ABBV-075 has the same or better efficacy than other standard care agents.
Last Update：2024-04-09 21:01:54
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Product Name: Mivebresib(ABBV-075) Visit Supplier Webpage Request for quotationCAS: 1445993-26-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Spot supply
Product Name: Mivebresib Visit Supplier Webpage Request for quotationCAS: 1445993-26-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: ABBV-075 Visit Supplier Webpage Request for quotationCAS: 1445993-26-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Mivebresib Visit Supplier Webpage Request for quotationCAS: 1445993-26-9
Tel: +16314854226
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Product List: View Catalog
Product Name: Mivebresib Visit Supplier Webpage Request for quotation
CAS: 1445993-26-9
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Email: 3008007409@qq.com
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CAS: 1445993-26-9
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Raw Materials for 1445993-26-9