147118-35-2

147118-35-2 - Names and Identifiers

Name	METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE
Synonyms	J-6 B-8 rosuvastatin interMediates J-6 Methyl (3R)-3-(tert-butyldimethylsilylox... Methyl(3R)-3-(tert-butyldimethylsiyloxy)-5-oxo-6-triphenylphosphoranylidenexanoate Methyl(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanate Methyl (3R)-3-(tert-butyldiMethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanate Methyl(3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranyildene hexanoate Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanate methyl-(3R)-3-[(terbutyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate Methyl(3r)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate methyl(3r)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenyl phosphoranylidene hexanoate METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE (3R)-3-(tert-butyldiMethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl ester METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE (J6)
CAS	147118-35-2
EINECS	604-562-3

147118-35-2 - Physico-chemical Properties

Molecular Formula	C31H39O4PSi
Molar Mass	534.7
Density	1.10±0.1 g/cm3(Predicted)
Melting Point	77.5-78.5℃
Boling Point	603.9±65.0 °C(Predicted)
Appearance	Pale yellow to white crystalline powder
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

147118-35-2 - Introduction

METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE, also known as TBDMSCI, is an organosilicon compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless liquid
-Molecular formula: C26H33O4PSi
-Molecular weight: 488.6g/mol
-Melting Point: 25-28 ℃
-Boiling point: 430 ℃ (expected)
-Density: 1.14 g/mL (expected)
-Soluble: Soluble in ethanol, ether and some organic solvents

Use:
- TBDMSCI is often used as a reagent in organic synthesis, especially in metal-catalyzed reactions
-It can be used to synthesize drugs, pesticides and other organic compounds, and is used to introduce functional groups such as phosphine groups, tert-butyl dimethylsilyl groups and ester groups
-As a modifier for ligands or catalysts, it can be used to regulate and accelerate organic reactions

Method:
- TBDMSCI can be obtained by reacting and synthesizing the corresponding raw materials. The specific preparation method may vary depending on the reaction conditions and requirements. The most common method of preparation involves reacting tert-butyldimethylammonium silicate with Formic Anhydride and triphenylphosphinene to form the desired product.

Safety Information:
- TBDMSCI may be irritating and corrosive to the skin and eyes, and should be avoided
-Wear appropriate personal protective equipment such as gloves and goggles during use
-When exposed to the compound, immediately flush the affected area with plenty of water and seek medical help
-During storage and use, avoid contact with fire and high temperature to prevent fire and explosion
-Should be stored in a cool, dry and well-ventilated place, away from oxidants and flammable materials

Please note that for the preparation and use of this compound, it is necessary to strictly follow the safety operating procedures of chemical laboratories and follow the advice and guidance of professionals in organic synthesis experiments.

Last Update：2024-04-09 19:05:46