1474034-05-3
RTA-408
CAS: 1474034-05-3
Molecular Formula: C33H44F2N2O3
1474034-05-3 - Names and Identifiers
1474034-05-3 - Physico-chemical Properties
| Molecular Formula | C33H44F2N2O3 |
| Molar Mass | 554.71 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Boling Point | 662.0±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 13.71±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | RTA408 effectively increased the expression of Nrf2 target genes in RAW 264.7 cells and reversed IFNγ-mediated inhibition of Gclc expression. In a panel of 8 human tumor cell lines, RTA 408 inhibited growth with a mean GI50 value of 260 nM and induced apoptosis. In tumor cells, RTA 408 also inhibits NF-κB and activates JNK. |
| In vivo study | In radiation-induced dermatitis mice, 1.0% RTA 408 significantly reduced epidermal and collagen thickness, prevented dermal necrosis, and completely alleviated skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also reduced hematopoietic acute radiation syndrome in mice. |
1474034-05-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.803 ml | 9.014 ml | 18.027 ml |
| 5 mM | 0.361 ml | 1.803 ml | 3.605 ml |
| 10 mM | 0.18 ml | 0.901 ml | 1.803 ml |
| 5 mM | 0.036 ml | 0.18 ml | 0.361 ml |
Last Update：2024-01-02 23:10:35
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View History
1474034-05-3
401566-79-8
158129-94-3
127296-34-8
1-Bromoctan
perfluorinatedmethylvinylether
o-Tolunitrile
Bacillussubtilis
促进剂DBTU
Rbidiumoxide
401566-79-8
158129-94-3
127296-34-8
1-Bromoctan
perfluorinatedmethylvinylether
o-Tolunitrile
Bacillussubtilis
促进剂DBTU
Rbidiumoxide