147687-17-0

147687-17-0 - Names and Identifiers

Name	9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one
Synonyms	4H-Pyrido[1 2-a]pyriMidin-4-one 3-(2-chloroethyl)-2-Methyl-9-(phenylMethoxy)- 9-Benxyloxy-3-(2-Chloro ethyl)-2-methyl pyrido[1,2-a]pyrimidine-4-one 3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidin-4-one 9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-Chloroethyl)-2-Methyl-9-(phenylMethoxy)-4H-pyrido[1,2-a]pyriMidin-4-one 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-(2-chloroethyl)-2-Methyl-9-(phenylMethoxy)- 3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone)
CAS	147687-17-0
EINECS	604-596-9
InChI	InChI=1/C18H17ClN2O2/c1-13-15(9-10-19)18(22)21-11-5-8-16(17(21)20-13)23-12-14-6-3-2-4-7-14/h2-8,11H,9-10,12H2,1H3

147687-17-0 - Physico-chemical Properties

Molecular Formula	C18H17ClN2O2
Molar Mass	328.79
Density	1.24±0.1 g/cm3(Predicted)
Melting Point	140-142°C
Boling Point	505.0±60.0 °C(Predicted)
Flash Point	259.2°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	2.53E-10mmHg at 25°C
Appearance	Solid
Color	Off-White to Beige
pKa	2.72±0.70(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.608

147687-17-0 - Introduction

9-benzyloxy-3-(2-chlorine ethyl)-2-methylpyrido [1,2-a]pyrimidine-4-one, also known as LK-6, is a chemical substance with the chemical formula C19H18ClNO2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: The LK-6 is a white crystalline solid.
-Melting point: About 150-153 degrees Celsius.
-Solubility: LK-6 has good solubility in common organic solvents.
-Stability: The LK-6 is relatively stable under regular storage conditions and is not easy to decompose.

Use:
-Anti-tumor activity: LK-6 has anti-tumor activity and can be used to inhibit the growth and spread of tumor cells.
-Drug research: LK-6 can be used as raw materials for drug research for the synthesis of more complex anti-tumor drugs.

Preparation Method:
The preparation method of LK-6 is more complicated, generally obtained by multi-step reaction:
1. First, 3-(2-chloroethyl)-2-methyl -4H-pyridine was synthesized by chemical reaction.
2. Then, on the basis of 3-(2-chloroethyl)-2-methyl-4h-pyridine, LK-6 was synthesized through a specific reaction.

Safety Information:
- LK-6 safety and toxicity information is limited and requires careful handling and compliance with relevant safety practices.
- LK-6 should be kept away from fire and high temperature, stored in a dry, well-ventilated place.
-Use appropriate protective equipment when using LK-6, including gloves, goggles, and laboratory clothing.
-In case of ingestion, inhalation or skin contact, seek medical attention and consult a professional doctor immediately.

Last Update：2024-04-09 21:01:54