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1513-65-1

2,6-Difluoropyridine

CAS: 1513-65-1

Molecular Formula: C5H3F2N

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1513-65-1 - Names and Identifiers

Name 2,6-Difluoropyridine
Synonyms 2,6-DifL
CCRIS 1720
NSC 331814
2,6-difluoropyridi
2,6-Difluorpyridin
2,6-Difluoropyridine
2,6-DIFLUOROPYRIDINE
Pyridine, 2,6-difluoro-
2, 6-2 fluoride pyridine
2,6- twofluorine pyridine
2-amino-6-(trifluoromethyl)pyrimidin-4-ol
CAS 1513-65-1
EINECS 216-152-8
InChI InChI=1/C5H4F3N3O/c6-5(7,8)2-1-3(12)11-4(9)10-2/h1H,(H3,9,10,11,12)
InChIKey MBTGBRYMJKYYOE-UHFFFAOYSA-N

1513-65-1 - Physico-chemical Properties

Molecular FormulaC5H3F2N
Molar Mass115.08
Density1.268 g/mL at 25 °C (lit.)
Boling Point124.5 °C/743 mmHg (lit.)
Flash Point93°F
Solubility Not miscible or difficult to mix.
Vapor Presure0.643mmHg at 25°C
AppearanceLiquid
Specific Gravity1.268
ColorClear purple-red
BRN1422549
pKa-6.09±0.10(Predicted)
Storage ConditionInert atmosphere,2-8°C
Refractive Indexn20/D 1.437(lit.)

1513-65-1 - Risk and Safety

Risk CodesR10 - Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS16 - Keep away from sources of ignition.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S37/39 - Wear suitable gloves and eye/face protection
UN IDsUN 1993 3/PG 3
WGK Germany3
FLUKA BRAND F CODES10
HS Code29333999
Hazard NoteToxic
Hazard Class3
Packing GroupIII

1513-65-1 - Reference Information

NIST chemical information information provided by: webbook.nist.gov (external link)
Application 2, 6-difluoropyridine is widely used in the production of pharmaceuticals, pesticides, rubber and dyes; is an important intermediate of pesticide chemicals, used in the preparation of herbicides and insecticides, has important medicinal value and development prospects.
preparation into a 500L enamel kettle, 252.2kg of sulfolane (1g/4ml) and 2, 6-dichloropyridine 50kg(1.0eq), then 43.2g of potassium fluoride (2.2eq) and 1.5kg of 18-crown -6(3%) were added in one time, stirred for 20min, then the temperature of the system is heated to 180~188 ℃, and the reaction is carried out at 180~188 ℃ for 6H. The product is transferred out of the reaction system by distillation in the reaction process, which drives the reaction to complete, the fractions were washed with water, separated, dried in organic phase, filtered, and the filtrate was Distilled. The fractions at 122~124 ℃ were collected, and the product was 30.4, yield 78.2%, GC purity: 99.5%.
Last Update:2024-04-09 15:16:45
1513-65-1
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