Name | KDU691 |
Synonyms | KDU691 KDU-691 KDU 691 1513879-19-0 Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]- |
CAS | 1513879-19-0 |
Molecular Formula | C22H18ClN5O2 |
Molar Mass | 419.86 |
Density | 1.35±0.1 g/cm3(Predicted) |
pKa | 14.59±0.46(Predicted) |
Storage Condition | -20℃ |
In vivo study | During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.382 ml | 11.909 ml | 23.817 ml |
5 mM | 0.476 ml | 2.382 ml | 4.763 ml |
10 mM | 0.238 ml | 1.191 ml | 2.382 ml |
5 mM | 0.048 ml | 0.238 ml | 0.476 ml |