152751-57-0
SEVELAMER HCL
CAS: 152751-57-0
Molecular Formula: C6H13Cl2NO
152751-57-0 - Names and Identifiers
| Name | SEVELAMER HCL |
| Synonyms | Sevelemar SEVELAMER HCL Sevelamer-001 Sevelamer Hydrochloride Sevelamer hydrochloride 2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride (ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride 2-Propen-1-aMine Hydrochloride polyMer with 2-(ChloroMethyl)oxirane |
| CAS | 152751-57-0 |
| EINECS | 682-522-4 |
| InChI | InChI=1/C3H5ClO.C3H7N/c4-1-3-2-5-3;1-2-3-4/h3H,1-2H2;2H,1,3-4H2 |
152751-57-0 - Physico-chemical Properties
| Molecular Formula | C6H13Cl2NO |
| Molar Mass | 186.08 |
| Boling Point | 116.1°C at 760 mmHg |
| Flash Point | 33.9°C |
| Vapor Presure | 22mmHg at 25°C |
| Storage Condition | 2-8℃ |
| In vivo study | In nephrectomized rats fed a high-phosphorus (HP) diet, Sevelamer was as effective as calcium carbonate, reduced serum phosphorus, calcium-phosphorus product, and slowed secondary hyperparathyroidism. Compared to control mice, Sevelamer was able to resolve leading to a significant reduction in calcium deposition in the myocardium and aorta. In rats with chronic renal failure, Sevelamer inhibited aortic calcification and also inhibited osteoid volume, fibrotic volume, and femoral porosity ratio. Sevelamer significantly reduced atherosclerosis and vascular calcification in uremic mice compared to uremic controls. In uremic mice, Sevelamer had an effect on both intimal and medial calcification. In uremic mice, Sevelamer treatment controls the increase in serum calcium independent of serum phosphorus, thereby reducing serum calcium and phosphorus and further deterioration of renal function, expressed as maximum creatinine clearance. Sevelamer is as effective as calcium carbonate in inhibiting high P-induced SH, as marked by similar serum PTH levels, parathyroid gland weight (PT) and PT hyperplasia. Sevelamer resulted in a significant reduction in renal calcium deposition compared to the uremic high-P diet (U-HP) and the U-HP calcium carbonate diet. In uremic mice, Sevelamer hydrochloride caused a decrease in urinary pH and an increase in urinary ammonium and calcium excretion, consistent with net acid excretion in animal models. |
152751-57-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.684 ml | 33.418 ml | 66.836 ml |
| 5 mM | 1.337 ml | 6.684 ml | 13.367 ml |
| 10 mM | 0.668 ml | 3.342 ml | 6.684 ml |
| 5 mM | 0.134 ml | 0.668 ml | 1.337 ml |
Last Update：2024-01-02 23:10:35
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QQ: 2881950922
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Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Sevelamer hydrochloride Visit Supplier Webpage Request for quotation
CAS: 152751-57-0
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CAS: 152751-57-0
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