154057-58-6
[2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido
CAS: 154057-58-6
Molecular Formula: C37H30BrFNP
154057-58-6 - Names and Identifiers
154057-58-6 - Physico-chemical Properties
| Molecular Formula | C37H30BrFNP |
| Molar Mass | 618.5169642 |
| Melting Point | 218-225℃ |
| Solubility | Chloroform (Slightly), DMSO (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Irritant |
| MDL | MFCD19440813 |
154057-58-6 - Reference Information
| Mechanism of action | The mechanism of action of pitavastatin calcium intermediate is currently believed to inhibit the rate-limiting enzyme in the early stage of intracellular cholesterol synthesis, that is, HMG-COA reductase, It reduces free cholesterol in the cell, and then feeds the expression of low-density lipoprotein (LDL) receptors on the surface of the cells, increasing the number of LDL receptors in the cell and enhancing the activity, the clearance of very low density lipoprotein (VLDL) residues or medium density lipoprotein (IDL) and LDL in the circulating blood was accelerated. In addition, it can also inhibit the synthesis of VLDL in liver. Its effect on reducing total cholesterol (TC) and LDL-C is obvious, and it also reduces triglyceride (TG) and increases high density lipoprotein cholesterol (HDL-C). |
| pharmacology | the pharmacology of pitavastatin calcium is as follows:(1) inhibition of HMG-CoA reductase pitavastatin calcium has a strong antagonistic inhibitory effect on HMG-Co a enzyme with an IC50 value of 6.8n M, and its intensity is 2.4 times that of simvastatin and 6.8 times that of fluvastatin. (2) Obtaining the synthesis of cholesterol. Pitavastatin calcium can effectively inhibit the process of cholesterol generation in human hepatocytes Hep G2, with IC50 value of 5.8nM, and its intensity is 2.9 times that of simvastatin and 5.7 times that of atorvastatin. However, pitavastatin calcium has a very weak inhibitory effect on the cholesterol production process after mevalonate production. (3) Increasing LDL receptor density Pitavastatin calcium can induce the synthesis of LDS receptor mRNA at an ultra-low concentration of 1 μM, increasing its number, resulting in an increase in LDL receptor density, thereby promoting the clearance of LDL and reducing plasma LDL-cholesterol concentration and plasma total triglyceride concentration. |
Last Update：2024-04-10 22:29:15
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View History
154057-58-6
Phenylphosphonic acid hydrogen pentyl ester
安倍生坦杂质3
24817-51-4
113825-16-4
活性艳红 KE-7B
2,5-Dithiobiurea
Tetraethyleneglycol
Aminoethanesulfonic acid
Di-n-amyl ether
Phenylphosphonic acid hydrogen pentyl ester
安倍生坦杂质3
24817-51-4
113825-16-4
活性艳红 KE-7B
2,5-Dithiobiurea
Tetraethyleneglycol
Aminoethanesulfonic acid
Di-n-amyl ether