154934-97-1

154934-97-1 - Names and Identifiers

Name	5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one
Synonyms	5-ETHOXYCARBONYL-4-(TRIFLUOROMETHYL)PYRIMIDIN-2(1H)-ONE 5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one Ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ETHYL 2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ethyl 2-oxo-6-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate Ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ETHYL 2-OXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLATE 2-Hydroxy-4-trifluoromethyl-pyrimidine-5-carboxylic acid ethyl ester Ethyl 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyrimidine-5-carboxylate, tech 2-Oxo-6-trifluoroMethyl-1,2-dihydro-pyriMidine-5-carboxylic acid ethyl ester Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate, Ethyl 1,2-dihydro-2-oxo-4-(trifluoromethyl)pyrimidine-5-carboxylate
CAS	154934-97-1
InChI	InChI=1/C8H7F3N2O3/c1-2-16-6(14)4-3-12-7(15)13-5(4)8(9,10)11/h3H,2H2,1H3,(H,12,13,15)

154934-97-1 - Physico-chemical Properties

Molecular Formula	C8H7F3N2O3
Molar Mass	236.15
Density	1.50±0.1 g/cm3(Predicted)
Melting Point	165 °C
Boling Point	381.7°C at 760 mmHg
Flash Point	184.6°C
Vapor Presure	2.27E-06mmHg at 25°C
pKa	5.03±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.499

154934-97-1 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection
HS Code	29335990
Hazard Note	Irritant

154934-97-1 - Introduction

5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one, also known as 2-hydroxy-4-trifluoromethylpyrimidine formate, is an organic compound. Its chemical formula is C7H5F3N2O3.

Nature:
-Appearance: It is usually a colorless or light yellow liquid.
-Solubility: Soluble in organic solvents such as ethanol, acetone and methanol.
-Melting point: about 35-37 ° C.
-Boiling point: About 154-158 ° C.

Use:
5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one is an important pharmaceutical intermediate with a wide range of applications:
-For the synthesis of anti-tumor drugs and other biologically active compounds.
-As a DNA methyltransferase inhibitor, used to study DNA methylation modification and cancer treatment.
-Used in the synthesis of fungicides, pesticides and other agricultural chemicals.

Method:
The preparation method of 5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one is more complicated and usually requires a multi-step reaction. One common method of preparation is by reacting 2-amino -4-trifluoromethylpyrimidine with ethyl formate.

Safety Information:
Regarding the safety of 5-Ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1H)-one, due to the potential risks to the human body and the environment, the following are some safety precautions:
-The compound should be handled under appropriate laboratory conditions and follow relevant safe operating procedures.
-This compound may be irritating to the eyes and skin, so take appropriate protective measures when exposed, such as wearing gloves and protective glasses.
-Avoid inhaling gas or solution vapor during operation and maintain good ventilation.
-Store the compound properly, dispose of waste properly after use, and follow local codes and regulations.

Last Update：2024-04-09 21:54:55