156-54-7
Sodium butyrate
CAS: 156-54-7
Molecular Formula: C4H7NaO2
156-54-7 - Names and Identifiers
| Name | Sodium butyrate |
| Synonyms | NAB Natriumbutyrat butyratesodium SODIUM BUTYRATE Sodium butyrate BUTYRIC ACID NA SODIUM BUTANOATE SODIUM N-BUTYRATE SODIUMBUTYRATE,USP N-BUTYRIC ACID, SODIUM Butanoicacidsodiumsalt Butanoicacid,sodiumsalt sodiumpropanecarboxylate BUTYRIC ACID SODIUM SALT Butyric acid, sodium salt Butanoic acid, sodium salt N-BUTYRIC ACID SODIUM SALT |
| CAS | 156-54-7 |
| EINECS | 205-857-6 |
| InChI | InChI=1/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 |
156-54-7 - Physico-chemical Properties
| Molecular Formula | C4H7NaO2 |
| Molar Mass | 110.09 |
| Density | 1.324 g/cm3 (30℃) |
| Melting Point | 250-253 °C (lit.) |
| Boling Point | 164.3°C at 760 mmHg |
| Flash Point | 69.7°C |
| Water Solubility | soluble |
| Solubility | Soluble in water, insoluble in ether. |
| Vapor Presure | 1.35mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| BRN | 3629439 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong acids. |
| Sensitive | Hygroscopic |
| MDL | MFCD00002816 |
| Physical and Chemical Properties | Water-soluble
|
| Use | Reduces intracellular Ca2 + release. Inhibit histone deacetylase (HDAC) and induce apoptosis. |
| In vitro study | Butyrate mediates growth inhibition of colon cancer cells, thereby elucidating the molecular link between a high-fiber diet and suppression of colon carcinogenesis. The Butyrate induces the expression of p21 mRNA in an immediate early manner, through the 1.4KB promoter cis-element (s) located at the transcription start site, independent of p53 binding transactivation. Butyrate induced apoptosis in 2 adenoma cell lines RG/C2 and AA/Cl and cancer cell line PC/JW/FI at physiological concentrations. Butyrate has powerful effects on a variety of colonic mucosa, such as inhibiting inflammation and tumorigenesis, strengthening various components of the colonic defense barrier and reducing oxidative stress. Butyrate inhibited most HDAC except Class III HDAC and class II HDAC6 and -10. Butyrate is also the most effective fatty acid to stimulate or inhibit the expression of specific genes. |
| In vivo study | In a dose-dependent manner, Butyrate sodium significantly prolonged survival, increased body weight and exercise capacity, and delayed the pathological sequelae in an R6 /2 transgenic mouse model of Huntington's disease (HD). Butyrate sodium salt also increases histone and specific protein -1 acetylation and protects against 3-nitropropionic neurotoxicity. |
156-54-7 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. |
| RTECS | ET6400000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29156000 |
156-54-7 - Reference
| Reference Show more | 1. Zhao, Penghui, et al. "Long-lasting effects of postweaning sodium butyrate exposure on social behaviors in adult mice." Brain Research Bulletin 165 (2020): 209-217.https://doi.org/10.1016/j.brainresbull.2020.09.014 2. [IF=4.192] Jing Liu et al."Sodium Butyrate Inhibits the Inflammation of Lipopolysaccharide-Induced Acute Lung Injury in Mice by Regulating the Toll-Like Receptor 4/Nuclear Factor κB Signaling Pathway."J Agr Food Chem. 2019;67(6):1674–1682 3. [IF=4.677] Xu Xiaohan et al."Gut Microbial Metabolite Short-Chain Fatt Acids Partially Reverse Surgery and Anesthesia-Induced Behavior Deficits in C57BL/6J Mice."Front Neurosci-Switz. 2021 Jun;0:593 4. [IF=4.077] Penghui Zhao et al."Long-lasting effects of postweaning sodium butyrate exposure on social behaviors in adult mice."Brain Res Bull. 2020 Dec;165:209 |
156-54-7 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| feed additive | sodium butyrate is one of the allowed feed additive varieties in our country and was listed in the "feed additive variety list" by the Ministry of agriculture in 2006. The application method in animal production is mainly to add sodium butyrate products to animal feed, which plays the role of intestinal mucosal nutrients, electrolyte balance regulators, gastrointestinal microecological regulators, compound acidulants, flavors, and food attractants. |
| Biological activity | Sodium butyrate (NaB, Butanoic acid sodium salt), is the sodium salt form of butyrate. It is a histone deacetylase(HDAC) inhibitor that competitively binds to the zinc regions of class I and class II HDACs. Sodium butyrate (NaB) can inhibit cell cycle progression, promote differentiation and induce apoptosis and autophagy in many types of cancer cells. |
| Target | Value |
| use | reduce intracellular Ca2 + release. Inhibit histone deacetylase (HDAC) and induce apoptosis. |
| category | toxic substances |
| flammability hazard characteristics | combustible, sodium oxide pungent smoke from the fire site |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| fire extinguishing agent | water, carbon dioxide, dry powder, foam |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:48
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