156478-71-6
4-Boc-1-piperazineacetic acid
CAS: 156478-71-6
Molecular Formula: C11H20N2O4
156478-71-6 - Names and Identifiers
156478-71-6 - Physico-chemical Properties
| Molecular Formula | C11H20N2O4 |
| Molar Mass | 244.29 |
| Density | 1.174 |
| Boling Point | 365.5±37.0 °C(Predicted) |
| Flash Point | 174.851°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 2.40±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.501 |
| MDL | MFCD02682402 |
156478-71-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
156478-71-6 - Reference Information
| Uses | 4-Boc-1-piperazine acetic acid is an organic intermediate. |
| Preparation | 4-Boc-1-piperazine acetic acid can be prepared from piperazine-1-carboxylic acid tert-butyl ester as raw material. 4-(2-ethoxy-2-oxoethyl) piperazin-1-carboxylic acid tert-butyl ester, and then hydrolyze the ester group to obtain 4-Boc-1-piperazinacetic acid. Potassium carbonate (3.71g,26.8mmol) and ethyl bromoacetate (1.2mL,10.8mmol) were added to DMF(14mL) solution of stirred piperazine-1-carboxylate (2g,10.7mmol) under room temperature and inert atmosphere. The reaction mixture was stirred at room temperature for 16h. After consumption of the feedstock (monitored by TLC), the reaction mixture was diluted with water (50mL) and extracted with EtOAc(2 × 50mL). The combined organic extract was dried with anhydrous Na2SO4 and concentrated under reduced pressure to obtain 4-(2-ethoxy-2-oxoethyl) piperazine-1-carboxylic acid tert-butyl ester (2.8g,10.29mmol,95%) as a yellow oil. 1H NMR(500MHz,DMSO-d6):δ4.12-4.00(m,2H),3.30(s,4H),3.23(s,2H),2.45(t,J = 4.6Hz,4H),1.39(s,9H),1.18(t,J = 7.1Hz,3H)4-Boc-1-piperazine acetic acid at 0 ℃, lithium hydroxide (1.29g,30.8mmol) was added to a solution of a mixture of stirred 4-(2-ethoxy-2-oxoethyl) piperazine-1-carboxylic acid tert-butyl ester (2.8g,10.29mmol) of THF ∶ MeOH ∶ water (3:1 ∶ 1,30mL). The reaction mixture was gradually warmed to room temperature and stirred for 3h. After consumption of the feedstock (monitored by TLC), the volatiles were concentrated under reduced pressure. The residue was then acidified to pH 4 to pH 5 with a 5% citric acid solution and extracted with EtOAc(2 × 100mL). The combined organic extract was dried with anhydrous Na2SO4 and concentrated under reduced pressure to obtain 4-Boc-1-piperazine acetic acid (200mg, crude) as a yellow oil, which can be used in the next step without further purification. LC-MS: m/z 245.1[M-H] (purity 71.81%) at 1.06RT. |
Last Update：2024-04-09 20:52:54
Supplier List
Featured ProductsSpot supply
Product Name: 4-Boc-1-piperazineacetic acid Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)acetic acid Request for quotationCAS: 156478-71-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 4-Boc-1-piperazineacetic acid Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 1-Boc-4-carboxymethyl piperazine Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 4-Boc-1-Piperazineacetic Acid Visit Supplier Webpage Request for quotation
CAS: 156478-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 156478-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 4-Boc-1-piperazineacetic acid Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)acetic acid Request for quotationCAS: 156478-71-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 4-Boc-1-piperazineacetic acid Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 1-Boc-4-carboxymethyl piperazine Visit Supplier Webpage Request for quotationCAS: 156478-71-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 4-Boc-1-Piperazineacetic Acid Visit Supplier Webpage Request for quotation
CAS: 156478-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 156478-71-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History