158722-22-6
(4S,5R)-2,4-Diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylic acid
CAS: 158722-22-6
Molecular Formula: C16H13NO3
158722-22-6 - Names and Identifiers
| Name | (4S,5R)-2,4-Diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylic acid |
| Synonyms | Said chain of Paclitaxel 2 (4S,5R)-2,4-Diphenyl-4,5-dihydrooxazole-5-carboxylicaci (4S,5R)-4,5-Dihydro-2,4-Diphenyloxazole-5-Carboxylic Acid (4S,5R)-4,5-dihydro-2,4-diphenyloxazole-5-carboxylic acid (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid 5-Oxazolecarboxylic acid, 4,5-dihydro-2,4-diphenyl-, (4S,5R)- (4S,5R)-2,4-Diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylic acid (4S,5R)-2,4-Diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylic ac... |
| CAS | 158722-22-6 |
| InChI | InChI=1S/C16H13NO3/c18-16(19)14-13(11-7-3-1-4-8-11)17-15(20-14)12-9-5-2-6-10-12/h1-10,13-14H,(H,18,19)/t13-,14+/m0/s1 |
158722-22-6 - Physico-chemical Properties
| Molecular Formula | C16H13NO3 |
| Molar Mass | 267.28 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 203-204℃ |
| Boling Point | 486.3±45.0 °C(Predicted) |
| pKa | 0.87±0.60(Predicted) |
| Storage Condition | 2-8°C |
158722-22-6 - Reference Information
| Overview | 2,4-diphenyl-oxyazacycl-5-acid is a pharmaceutical intermediate that can be made of (2R,3S)-3-Phenyliserine and trimethyl orthobenzoate are prepared in two steps. 2, 4-diphenyl-oxyazacycl-5-acid is a pharmaceutical intermediate, which can be produced by (2R,3S)-3-phenylisoserine and trimethyl orthobenzoate through two steps. It has been reported in the literature that 2, 4-diphenyl-oxyazacycl-5-acid can be used to introduce substituents at the C- 13 and C- 14 positions of paclitaxel, and retain the ring skeleton and necessary functional groups of taxanes. The obtained compound has the anticancer biological activity of natural paclitaxel and has certain application prospects in reducing the toxic and side effects of natural paclitaxel. |
| application | 2, 4-diphenyl-oxynitrogen heterocyclic -5-acid can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical medicine synthesis process, mainly as paclitaxel side chain. |
Last Update：2024-04-09 15:16:48
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