Molecular Formula | C159H252N46O48 |
Molar Mass | 3575.98 |
Storage Condition | -20°C |
In vitro study | Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist. Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells. |
WGK Germany | 3 |
biological activity | Adrenomedullin (AM) (22-52), human,NH2 end truncated adrenomedullin analog, is adrenomedullin (adrenomedullin receptor) receptor antagonist, and is also in the vascular bed of the hind limb of the cat, it also has an antagonistic effect on calcitonin gene-related peptide (CGRP) receptors. |
target | Adrenomedullin receptor, CGRP receptor |
in vitro research | Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist. Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells. |