160232-08-6

160232-08-6 - Names and Identifiers

Name	tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate
Synonyms	(2R,3S)-3-(Boc-amino)-1-(isobutylamino)-4-phenyl-2-butanol tert-Butyl[(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate tert-Butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate tert-butyl {(1S,2R)-1-benzyl-2-hydroxy-3-[(2-methylpropyl)amino]propyl}carbamate ([1S,2R]-(1-Benzyl-2-hydroxy-3-(isobutyl-amino)propyl)carbamic acid tert-butylester tert-butyl N-[(2S,3R)-3-hydroxy-4-(2-methylpropylamino)-1-phenylbutan-2-yl]carbamate N-[3-hydroxy-4-(2-methylpropylamino)-1-phenylbutan-2-yl]carbamic acid tert-butyl ester N-[(1S,2R)-2-Hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester Carbamicacid,N-[(1S,2R)-2-hydroxy-3-[(2-methylpropyl)amino]-1-(phenylmethyl)propyl]-,1,1-dimethylethyl ester
CAS	160232-08-6
EINECS	605-203-3
InChI	InChI=1/C19H32N2O3/c1-14(2)12-20-13-17(22)16(11-15-9-7-6-8-10-15)21-18(23)24-19(3,4)5/h6-10,14,16-17,20,22H,11-13H2,1-5H3,(H,21,23)/t16-,17+/m0/s1

160232-08-6 - Physico-chemical Properties

Molecular Formula	C19H32N2O3
Molar Mass	336.47
Density	1.039±0.06 g/cm3(Predicted)
Melting Point	145 °C
Boling Point	484.7±45.0 °C(Predicted)
Flash Point	246.936°C
Solubility	Chloroform, Dichloromethane, Methanol
Vapor Presure	0mmHg at 25°C
Appearance	White solid
Color	White
pKa	12.07±0.46(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.512

160232-08-6 - Introduction

tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate is an organic compound. The following is an introduction to its properties, uses, preparation methods and safety information:

Nature:
-Appearance: colorless liquid
-Molecular formula: C15H23NO2
-Molecular weight: 249.35g/mol
-Melting point: no obvious melting point
-Boiling point: about 190-195 ° C (0.7 mmHg)
-Solubility: Soluble in organic solvents such as alcohols, ethers and ketones, insoluble in water.

Use:
tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino) prodrug] carbamate is mainly used in drug synthesis and organic chemical reactions. It can be used as an intermediate for the synthesis of other compounds, especially in the study of protein phosphatase inhibitors.

Preparation Method:
The preparation method of tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate is relatively complicated and involves multi-step reactions. A typical synthetic route involves the following steps:
1. Synthesis of amino acid derivatives using appropriate starting materials.
2. Nucleophilic substitution reaction is carried out under alkaline conditions to introduce phenyl and methylpropyl groups.
3. The Bitwood rearrangement reaction is carried out under appropriate conditions to form the target compound.

Safety Information:
Specific safety information for tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate may vary by manufacturer. Due to the lack of detailed information, it is recommended to take appropriate laboratory safety measures when using or handling the compound, such as wearing protective gloves, glasses and protective clothing, and to ensure that it is operated in a well-ventilated environment. Also, dispose of in accordance with local regulations. If further information is required, please refer to the safety data sheet (SDS) of the compound or contact the supplier.

Last Update：2024-04-09 15:16:35