162012-72-8
6-Methoxy-7-Hydroxyquinazolin-4-One
CAS: 162012-72-8
Molecular Formula: C9H8N2O3
162012-72-8 - Names and Identifiers
162012-72-8 - Physico-chemical Properties
| Molecular Formula | C9H8N2O3 |
| Molar Mass | 192.17 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Melting Point | >255oC (dec.) |
| Boling Point | 420.0±55.0 °C(Predicted) |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | Light Beige |
| pKa | 8.07±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
162012-72-8 - Reference Information
| Introduction | 6-methoxy-7-hydroxyquinazolin-4-one is a pharmaceutical intermediate used to prepare gefitinib. Gefitinib (Gefitinib), whose chemical name is 4-(3-chloro-4-fluoroanilino) -7-methoxy-6-(3-morpholinyl propoxy) quinazoline, is a protein tyrosine kinase inhibitor developed by AstraZeneca (AstraZeneca). |
| Uses | 6-methoxy-7-hydroxyquinazolin-4-one is a ketone organic substance and can be used as a pharmaceutical intermediate. |
| preparation | weigh 1mmol of 2-iodine (bromine)-4-methoxy -5-hydroxybenzonitrile, 1.5mmol of formamidine hydrochloride in 10mL of aqueous phase, add 0.1mmol of CuI catalyst, alkali K2CO33mmol, microwave heating and reflux at 80 ℃ for 0.5h, and microwave power 150W. After the reaction, cool to room temperature and filter to obtain solid powder. |
Last Update：2024-04-09 20:49:11
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