1622-55-5

1622-55-5 - Names and Identifiers

Name	9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one
Synonyms	Pizotifen Impurity 1 4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-one 9,10-Dihydro-4H-benzo[4,5]cyclohepta[b]-thiophen-4-one 9,10-DIHYDRO-4-H-BENZO{4,5}CYCLOHEPTA-{1,2-B}-4-THIOPHENE 9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]-4-thiophenone 9,10-Dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thiophen-4-one 9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one 4-oxo-9,10-dihydro-4h-benzo(4,5)cyclohepto(1,2.b)thiophene 4-Oxo-9,10-Dihydro-4H-Benzo(4,5)-Cyclohepta-(1,2B)Thiophene 4H-Benzo[4,5]cyclohepta[1,2-b]thiophen-4-one, 9,10-dihydro-
CAS	1622-55-5
InChI	InChI=1/C13H10OS/c14-13-10-4-2-1-3-9(10)5-6-12-11(13)7-8-15-12/h1-4,7-8H,5-6H2

1622-55-5 - Physico-chemical Properties

Molecular Formula	C13H10OS
Molar Mass	214.28
Density	1.262±0.06 g/cm3(Predicted)
Boling Point	125-140 °C(Press: 0.05 Torr)
Flash Point	178.2°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	1.06E-05mmHg at 25°C
Appearance	Brown Semi-Solid
Storage Condition	Refrigerator
Refractive Index	1.644
Physical and Chemical Properties	Liquid compounds. Boiling point 165-180 °c/27-68PA, refractive index (nD22)1.6520-6548.
Use	An intermediate of ketotifen and thiacridine.

1622-55-5 - Reference Information

Use

An intermediate of ketotifen and phenyclidine.

Production method

Thiophene is chloromethylated with formaldehyde and concentrated hydrochloric acid to generate 2-(chloromethyl) thiophene, and then heated with triethyl phosphite to obtain 2-thiophene methylphosphonic acid diethyl ester, which is condensed with o-carboxybenzaldehyde under the participation of sodium methoxide to obtain 2-[β-(2-thiophene) vinyl] benzoic acid; then it is catalyzed by palladium-carbon hydrogenation, reduction of vinyl, and finally cyclization under the action of polyphosphoric acid to obtain the product.

Last Update：2024-04-09 20:45:29