163222-32-0

163222-32-0 - Names and Identifiers

Name	Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)phenyl]-, (3R,4S)-
Synonyms	4'-O-Benzyloxy Ezetimibe (3R,4S)-4-[(4-Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-2-azetidinone (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one (3R,4S)-4-(4-(Benzyloxy)Phenyl)-1-(4-Fluorophenyl)-3-((S)-3-(4- Fluorophenyl)-3-Hydroxypropyl)Azetidin-2-One 1-(4-Fluorophenyl)-3-[(3s)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)Phenyl-(3r,4s)-2-Azetidinone (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-Hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-2-azetidinone (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-2-azetidinone 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)pheyl]-, (3R,4S)-2-Azetidinone 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)-2-AZETIDINONE Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)phenyl]-, (3R,4S)- 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-, (3R,4S)- 2-Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-Hydroxypropyl]-4-[4-(Phenylmethoxy)Phenyl]-, (3R,4S)- 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)- 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-phenylmethoxy]phenyl]-(3R,4S)-2-azetidinone (intermediate of ezetimibe)
CAS	163222-32-0
InChI	InChI=1/C31H27F2NO3/c32-24-10-6-22(7-11-24)29(35)19-18-28-30(34(31(28)36)26-14-12-25(33)13-15-26)23-8-16-27(17-9-23)37-20-21-4-2-1-3-5-21/h1-17,28-30,35H,18-20H2/t28-,29+,30-/m1/s1

163222-32-0 - Physico-chemical Properties

Molecular Formula	C31H27F2NO3
Molar Mass	499.55
Density	1.270
Melting Point	176 - 178°C
Boling Point	706.5±60.0 °C(Predicted)
Flash Point	381.055°C
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Vapor Presure	0mmHg at 25°C
Appearance	grayish white solid
Color	Off-White
pKa	14.15±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.617

163222-32-0 - Introduction

Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypyl]-4-[4-(Phenylmethoxy)phenyl]-, (3R,4S)-is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: The compound is a solid, usually a white or off-white crystalline substance.
-Molecular formula: C26H23F2NO2.
-Molecular weight: 437.47g/mol.
-Melting point: about 165-167 ℃.
-Solubility: better solubility in some organic solvents.

Use:
- Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypyl]-4-[4-(Phenylmethoxy)phenyl]-, (3R,4S)-can be used to synthesize other organic compounds, especially has potential application value in drug synthesis.
-This compound is an important intermediate that can be used to synthesize biologically active compounds.

Method:
Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypyl]-4-[4-(Phenylmethoxy)phenyl]-, methods for the preparation of (3R,4S)-typically involve a multi-step synthesis. Specific synthetic routes may involve a variety of organic synthesis reactions, such as substitution reactions, condensation reactions, oxidation reactions, etc.

Safety Information:
Since there is no specific mention of the safety record of the compound, it is recommended to follow the safe operating procedures of general chemical experiments when using or handling the compound. The use of chemicals should be subject to appropriate protective measures, such as wearing protective glasses, gloves and laboratory coats to avoid contact with skin and eyes. At the same time, it should be operated in a well-ventilated laboratory environment to avoid inhalation of harmful gases and vapors. When handling and storing, follow proper waste disposal practices. For more specific safety information, please consult the chemical product supplier or the relevant safety database.

Last Update：2024-04-09 21:11:58