165049-28-5

165049-28-5 - Names and Identifiers

Name	5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate (non-preferred name)
Synonyms	benzamido) PeMetrexed disodiuM INT-5 N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-glutaMic acid (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pe (S)-Diethyl 2-(4-(2-(2-aMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioate 4-Methylbenzenesulfonate N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate N-[4-[2-(2-Amino-4,7-Dihydro-4-Oxo-3h-Pyrrolo[2,3- D]Pyrimidin-5-Yl)Ethyl]Benzoyl]-L-Glutamic Acid-1,5-Diethyl Ester 4-Ethylbenzene Sulfonate 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbaMoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-2-aMiniuM 4-Methylbenzenesulfonate (non-preferred naMe) 5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium 4-methylbenzenesulfonate (non-preferred name)
CAS	165049-28-5
EINECS	605-383-3
InChI	InChI=1/C24H29N5O6.C7H8O3S/c1-3-34-18(30)12-11-17(23(33)35-4-2)27-21(31)15-8-5-14(6-9-15)7-10-16-13-26-20-19(16)22(32)29-24(25)28-20;1-6-2-4-7(5-3-6)11(8,9)10/h5-6,8-9,13,17H,3-4,7,10-12H2,1-2H3,(H,27,31)(H4,25,26,28,29,32);2-5H,1H3,(H,8,9,10)/t17-;/m0./s1

165049-28-5 - Physico-chemical Properties

Molecular Formula	C24H29N5O6.C7H8O3S
Molar Mass	655.725
Melting Point	>237oC (dec.)
Solubility	Dichloromethane (Very Slightly), DMF (Slightly, Sonicated), DMSO (Slightly)
Appearance	Solid
Color	Off-White to Pale Brown
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature

165049-28-5 - Introduction

N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is an organic compound, also known as ADEPT, whose chemical structure contains Benzoyl, glutamic acid Diethyl ester and pyrrole [2,3-D] Pyrimidine structural unit. It is a white to pale yellow solid.

The main properties and uses of this substance are as follows:
1. Nature: it is soluble in organic solvents, and insoluble in water. It is a stable compound capable of long-term storage at room temperature.
2. Use: N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is mainly used as a drug carrier. It can be used to deliver antineoplastic drugs such as tosylate. Due to its special chemical structure, it can increase the selectivity and efficacy of drugs, while reducing the toxicity to normal cells.
3. Preparation: N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2,3-d] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester is obtained by chemical synthesis. Specific synthetic methods may involve multiple reactions and the use of specific reagents.
4. Safety information: Due to the lack of specific safety data, for N-[4-[2-(2-amino -4, 7-dihydro-4-oxo-1h-pyrrole [2, the safety of 3-D] pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid Diethyl ester requires further study and evaluation. Appropriate laboratory safety practices and procedures should be followed when handling and using the compound, including wearing protective gloves, goggles and laboratory clothing to avoid direct contact with skin and inhalation of its dust. If necessary, work in a well-ventilated area.

Last Update：2024-04-09 19:05:47