165528-81-4
(2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS: 165528-81-4
Molecular Formula: C12H24N2O2
165528-81-4 - Names and Identifiers
| Name | (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER |
| Synonyms | 4-(BOC-AMINOETHYL)PIPERIDINE 4-(2-Boc-aminoethyl)piperidine 4-(2-BOC-AMINOETHYL) PIPERIDINE 4-(N-BOC-2-AMINOETHYL)PIPERIDINE 4-(2-BOC-AMINOETHYL)-1-PIPERIDINE TERT-BUTYL (2-PIPERIDIN-4-YLETHYL)CARBAMATE 4-(2-Aminoethyl)piperidine, 4-BOC protected 4-(2-Aminoethyl)piperidine, N2-BOC protected (2-PIPERIDIN-4-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER |
| CAS | 165528-81-4 |
| InChI | InChI=1/C12H24N2O2/c1-12(2,3)16-11(15)14-9-6-10-4-7-13-8-5-10/h10,13H,4-9H2,1-3H3,(H,14,15) |
165528-81-4 - Physico-chemical Properties
| Molecular Formula | C12H24N2O2 |
| Molar Mass | 228.33 |
| Density | 0.971±0.06 g/cm3(Predicted) |
| Boling Point | 337.3±15.0 °C(Predicted) |
| Flash Point | 157.8°C |
| Vapor Presure | 0.000106mmHg at 25°C |
| Appearance | Powder |
| pKa | 12.86±0.46(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.459 |
165528-81-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
165528-81-4 - Reference Information
| use | 4-(2-BOC-aminoethyl) piperidine is mainly used as a pharmaceutical intermediate, and it has been reported in the literature that it can be used to prepare SHP2 inhibitors. |
| preparation | the remaining oil is dissolved in 800 mL of 90% acetic acid and treated with 250 mg of catalyst (PtO2). The mixture was stirred in a hydrogen atmosphere at 35°C for 96 hours. The catalyst is removed by filtration and the solvent is evaporated. Dissolve the residue in water adjusted to pH 11 with 1N NaOH. The water layer was extracted with DCM 3 times. The organic layer was dried by Na2SO4 and the solvent was evaporated. The product crystallizes from the remaining oil at 4°C to give 4-(2-BOC-aminoethyl) piperidine (white solid; yield: 21.9g). |
Last Update：2024-04-09 02:00:00
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