165800-04-4
(S)-N-((3-(3-Fluoro-4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CAS: 165800-04-4
Molecular Formula: C18H23FN4O5
165800-04-4 - Names and Identifiers
165800-04-4 - Physico-chemical Properties
| Molecular Formula | C18H23FN4O5 |
| Molar Mass | 394.4 |
| Density | 1.370±0.06 g/cm3(Predicted) |
| Melting Point | 174-176℃ |
| Boling Point | 701.2±60.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 13.84±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | Eperezolid is a bioavailable synthetic antimicrobial agent with spectra of activity against antibiotic-susceptible and -resistant gram-positive pathogens. |
165800-04-4 - Reference
| Reference Show more | 1: Ford CW, Hamel JC, Wilson DM, Moerman JK, Stapert D, Yancey RJ Jr, Hutchinson DK, Barbachyn MR, Brickner SJ. In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob Agents Chemother. 1996 Jun;40(6):1508-13. PubMed PMID: 8726028; PubMed Central PMCID: PMC163358. 2: Zurenko GE, Yagi BH, Schaadt RD, Allison JW, Kilburn JO, Glickman SE, Hutchinson DK, Barbachyn MR, Brickner SJ. In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents. Antimicrob Agents Chemother. 1996 Apr;40(4):839-45. PubMed PMID: 8849237; PubMed Central PMCID: PMC163216. 3: Mason EO Jr, Lamberth LB, Kaplan SL. In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1996 Apr;40(4):1039-40. PubMed PMID: 8849225; PubMed Central PMCID: PMC163257. 4: Brickner SJ, Hutchinson DK, Barbachyn MR, Manninen PR, Ulanowicz DA, Garmon SA, Grega KC, Hendges SK, Toops DS, Ford CW, Zurenko GE. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J Med Chem. 1996 Feb 2;39(3):673-9. PubMed PMID: 8576909. |
165800-04-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.535 ml | 12.677 ml | 25.355 ml |
| 5 mM | 0.507 ml | 2.535 ml | 5.071 ml |
| 10 mM | 0.254 ml | 1.268 ml | 2.535 ml |
| 5 mM | 0.051 ml | 0.254 ml | 0.507 ml |
Last Update：2024-01-02 23:10:35
165800-04-4 - Reference Information
| biological activity | Eperezolid(PNU-100592) is an oxazolidinone antibiotic with good in vitro inhibition. |
Last Update：2024-04-09 19:05:05
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