166815-96-9

166815-96-9 - Names and Identifiers

Name	N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
Synonyms	tert-Butyl 4-((tosyloxy) N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl) N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylic acid tert-butyl ester 4-[(4-methylphenyl)sulfonyloxymethyl]-1-piperidinecarboxylic acid tert-butyl ester 1-PIPERIDINECARBOXYLIC ACID, 4-[[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER
CAS	166815-96-9
InChI	InChI=1/C18H27NO5S/c1-14-5-7-16(8-6-14)25(21,22)23-13-15-9-11-19(12-10-15)17(20)24-18(2,3)4/h5-8,15H,9-13H2,1-4H3

166815-96-9 - Physico-chemical Properties

Molecular Formula	C18H27NO5S
Molar Mass	369.48
Density	1.174±0.06 g/cm3(Predicted)
Melting Point	74-76℃
Boling Point	487.8±18.0 °C(Predicted)
Flash Point	248.803°C
Vapor Presure	0mmHg at 25°C
pKa	-1.94±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.526

166815-96-9 - Risk and Safety

Hazard Class

IRRITANT

166815-96-9 - Introduction

N-TERT-BUTOXYCARBONYL-4-PIPERIDINE is an organic compound whose chemical properties are as follows:

Nature:
-Molecular formula: C17H24N2O5S
-Molecular weight: 364.45g/mol
-Appearance: White or off-white crystalline powder
-Melting Point: 90-95 ℃
-Solubility: Soluble in esters, ethers, chlorinated hydrocarbons and other organic solvents

Use:
- N-TERT-BUTOXYCARBONYL-4-protecting group commonly used in organic synthesis. It can protect the amino group on the piperidine ring, and then remove the protecting group by acid or base treatment when necessary, so as to carry out the corresponding reaction.
-The compound can also be used as an intermediate in the pharmaceutical field and play an important role in the synthesis of drugs or drug research.

Synthetic method:
The preparation method of N-TERT-BUTOXYCARBONYL-4-(PIPERIDINE) can be carried out by the following steps:
1. Dissolve 1-piperidine methanol in dimethylformamide;
2. Adding appropriate amount of trimethylchlorosilane as catalyst;
3. Slowly add 4-(4-methylbenzenesulfonyl chloride) benzoate into the reaction system at low temperature;
4. After the reaction, process operations such as crystallization purification and drying are carried out.

Safety Information:
N-TERT-BUTOXYCARBONYL-4-(note) PIPERIDINE is an organic compound, the use of the following safety matters:
-Avoid contact with skin, eyes and mucous membranes, and use appropriate protective gloves, glasses and masks when working.
-Avoid inhaling its dust and ensure that it is operated in a well-ventilated environment.
-Store in a dry, cool place, away from fire and flammable substances.
-Pay attention to comply with laboratory safety practices and properly dispose of waste. For specific information or first aid, refer to the product's safety data sheet.

Last Update：2024-04-09 02:00:42