169243-86-1
(S)-N-FMOC-4-Fluorophenylalanine
CAS: 169243-86-1
Molecular Formula: C24H20FNO4
169243-86-1 - Names and Identifiers
| Name | (S)-N-FMOC-4-Fluorophenylalanine |
| Synonyms | Fmoc-Phe(4-F)-OH Fmoc-L-4-Fluorophe FMOC-L-4-Fluorophe FMOC-4-FLUORO-L-PHE FMOC-4-FLUORO-PHE-OH Fmoc-4-Fluoro-L-Phe-OH FMOC-4-FLUORO PHENYLALANINE Fmoc-L-4-Fluorophenylalanine FMOC-4-FLUORO-L-PHENYLALANINE Fmoc-4-Fluoro-L-phenylalanine (S)-N-FMOC-4-Fluorophenylalanine (9H-Fluoren-9-yl)MethOxy]Carbonyl Phe(4-F)-OH fluorenylmethoxycarbonyl-l-4-fluorophenylalanine N-(9-FLUORENYLMETHOXYCARBONYL)-4-FLUOROPHENYL-L-ALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-P-FLUORO-L-PHENYLALANINE |
| CAS | 169243-86-1 |
| InChI | InChI=1/C24H20FNO4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28)/p-1/t22-/m0/s1 |
169243-86-1 - Physico-chemical Properties
| Molecular Formula | C24H20FNO4 |
| Molar Mass | 405.42 |
| Density | 1.2642 (estimate) |
| Melting Point | 185.4 °C |
| Boling Point | 623.9±55.0 °C(Predicted) |
| Specific Rotation(α) | -35 º (c=1,DMF) |
| Flash Point | 331.1°C |
| Solubility | Soluble in Dimethylformamide(DMF). |
| Vapor Presure | 1.99E-16mmHg at 25°C |
| Appearance | White soft powder |
| BRN | 8287377 |
| pKa | 3.75±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00191197 |
169243-86-1 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S28 - After contact with skin, wash immediately with plenty of soap-suds. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | WGK 2 water endanger |
| HS Code | 29223990 |
| Hazard Note | Harmful |
169243-86-1 - Introduction
(S)-N-FMOC-4-Fluorophenylalanine is an amino acid derivative with the chemical name 9-fluorobiphenyl-2, 3-dihydroxypropionic acid. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(S)-N-FMOC-4-Fluorophenylalanine is a white to yellowish crystalline powder. Its molecular formula is C18H15FO4 and its molecular weight is 314.31g/mol. It has good solubility and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
Use:
(S)-N-FMOC-4-Fluorophenylalanine is a commonly used protecting group in chemical synthesis and is widely used in solid phase synthesis. It can be used as a building block for the synthesis of polypeptides, proteins or small organic compounds. During the synthesis, the desired compound structure is constructed by linking (S)-N-FMOC-4-Fluorophenylalanine to other amino acids.
Method:
The preparation of (S)-N-FMOC-4-Fluorophenylalanine generally involves a multi-step reaction. First, fluophenpropionic acid is reacted with stannous bromide by a chemical reaction to obtain a brominated product. The Bromo product and the Fmoc protecting group are then reacted by imidization to give the (S)-N-FMOC-4-Fluorophenylalanine.
Safety Information:
(S)-The N-FMOC-4-Fluorophenylalanine is relatively stable under normal operating conditions and does not pose a particularly serious safety risk. However, as a chemical, it is still necessary to comply with laboratory safety practices and avoid direct contact with eyes, skin and administration. In the operation should pay attention to the use of appropriate protective measures, such as wearing gloves, goggles and laboratory ventilation, to ensure safe use. If discomfort occurs, discontinue use immediately and seek medical help.
Nature:
(S)-N-FMOC-4-Fluorophenylalanine is a white to yellowish crystalline powder. Its molecular formula is C18H15FO4 and its molecular weight is 314.31g/mol. It has good solubility and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM).
Use:
(S)-N-FMOC-4-Fluorophenylalanine is a commonly used protecting group in chemical synthesis and is widely used in solid phase synthesis. It can be used as a building block for the synthesis of polypeptides, proteins or small organic compounds. During the synthesis, the desired compound structure is constructed by linking (S)-N-FMOC-4-Fluorophenylalanine to other amino acids.
Method:
The preparation of (S)-N-FMOC-4-Fluorophenylalanine generally involves a multi-step reaction. First, fluophenpropionic acid is reacted with stannous bromide by a chemical reaction to obtain a brominated product. The Bromo product and the Fmoc protecting group are then reacted by imidization to give the (S)-N-FMOC-4-Fluorophenylalanine.
Safety Information:
(S)-The N-FMOC-4-Fluorophenylalanine is relatively stable under normal operating conditions and does not pose a particularly serious safety risk. However, as a chemical, it is still necessary to comply with laboratory safety practices and avoid direct contact with eyes, skin and administration. In the operation should pay attention to the use of appropriate protective measures, such as wearing gloves, goggles and laboratory ventilation, to ensure safe use. If discomfort occurs, discontinue use immediately and seek medical help.
Last Update：2024-04-10 22:29:15
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