1717-59-5
2-(Fluorosulfonyl)difluoroacetic acid
CAS: 1717-59-5
Molecular Formula: C2HF3O4S
1717-59-5 - Names and Identifiers
1717-59-5 - Physico-chemical Properties
| Molecular Formula | C2HF3O4S |
| Molar Mass | 178.09 |
| Density | 1.723g/mLat 25°C(lit.) |
| Boling Point | 153°C(lit.) |
| Flash Point | >230°F |
| Water Solubility | It is soluble in water. |
| Vapor Presure | 0.158mmHg at 25°C |
| Appearance | liquid |
| Color | colorless |
| pKa | -0.38±0.10(Predicted) |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.36(lit.) |
| Physical and Chemical Properties | Sensitivity: motion Sensitive WGK Germany:3 |
1717-59-5 - Risk and Safety
| Risk Codes | R34 - Causes burns R35 - Causes severe burns R27/28 - |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 1760 8/PG 2 |
| WGK Germany | 3 |
| TSCA | No |
| HS Code | 29159000 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
1717-59-5 - Reference Information
| Application | 2-fluorosulfonyldifluoroacetic acid is a pharmaceutical intermediate, it can be prepared by reacting Tetrafluoroethane-beta-sultone with sodium hydroxide. It has been reported in the literature to be useful in the preparation of compounds against HIV. |
| preparation | an oven-dried 1000-mL three-necked round-bottom flask equipped with a magnetic stir bar, nitrogen (N2) inlet and gas outlet were added in a constant pressure funnel. Connect the gas outlet to an empty 500 ml spare trap and then to the inverted glass funnel outlet located directly above the 1000 mL beaker, the Beaker contained 120g NaOH in 600 ml of water. Anhydrous petroleum ether (400 mL) was added to the flask. Tetrafluoroethane-β-lactone (440g) and deionized water (44G, 2.44mol) were added dropwise to the mixture through an addition funnel with stirring. The mixture was cooled with an ice bath over 2 hours. After the addition was complete, the reaction mixture was gradually warmed to room temperature. The mixture was stirred at room temperature overnight. After purging with nitrogen for 1 hour to completely remove the HF remaining in the system, the reaction mixture was poured into a separatory funnel. The reaction mixture was separated. The lower crude oil was collected. The layer was distilled directly in vacuum. |
Last Update：2024-04-10 22:29:15
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View History
1717-59-5
Di(4-nitrophenyl) disulfide
125602-71-3
Acetic acid, phenyl-, methyl ester
147825-97-6
357277-61-3
153433-26-2
10143-38-1
1260092-32-7
Di(4-nitrophenyl) disulfide
125602-71-3
Acetic acid, phenyl-, methyl ester
147825-97-6
357277-61-3
153433-26-2
10143-38-1
1260092-32-7