172875-53-5
Olmesartan intermediate impurity I
CAS: 172875-53-5
Molecular Formula: C13H22N2O3
172875-53-5 - Names and Identifiers
172875-53-5 - Physico-chemical Properties
| Molecular Formula | C13H22N2O3 |
| Molar Mass | 254.33 |
| Density | 1.111±0.06 g/cm3(Predicted) |
| Boling Point | 464.9±35.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Gel |
| Color | Colourless |
| pKa | 12.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | Intermediate |
172875-53-5 - Introduction
imidazole monoethyl ester (Methyl imidazole) is a common impurity and is referred to as imidazolone for short. The following is a description of its nature, use, preparation and safety information:
Nature:
Olmesartan intermediate impurity I is a colorless liquid with a special odor. Its molecular formula is C4H6N2O and its molecular weight is 98.10g/mol. This impurity has moderate volatility and solubility and is soluble in water and organic solvents.
Use:
Olmesartan intermediate impurity I is a commonly used organic synthesis intermediate. It is commonly used in the fields of drug synthesis, dye synthesis and chemical synthesis. In organic synthesis, it is often used as a catalyst, reaction intermediary or hydroxide scavenger.
Method:
Olmesartan intermediate impurity I can be obtained by reacting imidazole with ethanol under appropriate conditions. This reaction is generally carried out at a higher temperature, the common method is heating under alkaline conditions, and the catalyst is often basic zinc oxide or basic zinc carbonate.
Safety Information:
The Olmesartan intermediate impurity I is generally less toxic. However, long-term exposure may cause irritation to the skin, eyes and respiratory tract. Therefore, when handling Olmesartan intermediate impurity I, correct laboratory safety procedures should be followed to avoid direct skin contact and inhalation. The Material Safety Data Sheet should be read carefully before use and relevant safety precautions should be followed.
Nature:
Olmesartan intermediate impurity I is a colorless liquid with a special odor. Its molecular formula is C4H6N2O and its molecular weight is 98.10g/mol. This impurity has moderate volatility and solubility and is soluble in water and organic solvents.
Use:
Olmesartan intermediate impurity I is a commonly used organic synthesis intermediate. It is commonly used in the fields of drug synthesis, dye synthesis and chemical synthesis. In organic synthesis, it is often used as a catalyst, reaction intermediary or hydroxide scavenger.
Method:
Olmesartan intermediate impurity I can be obtained by reacting imidazole with ethanol under appropriate conditions. This reaction is generally carried out at a higher temperature, the common method is heating under alkaline conditions, and the catalyst is often basic zinc oxide or basic zinc carbonate.
Safety Information:
The Olmesartan intermediate impurity I is generally less toxic. However, long-term exposure may cause irritation to the skin, eyes and respiratory tract. Therefore, when handling Olmesartan intermediate impurity I, correct laboratory safety procedures should be followed to avoid direct skin contact and inhalation. The Material Safety Data Sheet should be read carefully before use and relevant safety precautions should be followed.
Last Update：2024-04-09 20:48:19
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