175203-08-4
4-(4-chlorophenyl)pyrimidine-2-thiol
CAS: 175203-08-4
Molecular Formula: C10H7ClN2S
175203-08-4 - Names and Identifiers
175203-08-4 - Physico-chemical Properties
| Molecular Formula | C10H7ClN2S |
| Molar Mass | 222.69 |
| Density | 1.35g/cm3 |
| Melting Point | 210 °C |
| Boling Point | 357.1°C at 760 mmHg |
| Flash Point | 169.8°C |
| Vapor Presure | 2.79E-05mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.674 |
175203-08-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Irritant |
175203-08-4 - Introduction
4-(4-chlorophenyl)pyrimidine-2-thiol is an organic compound with the chemical formula C10H7ClN2S. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: 4-(4-chlorophenyl)pyrimidine-2-thiol is a white crystalline solid.
-Solubility: It is soluble in most organic solvents, such as methanol, ethanol and dichloromethane, but difficult to dissolve in water.
-Stability: The compound is relatively stable under regular environmental conditions.
Use:
- 4-(4-chlorophenyl)pyrimidine-2-thiol is widely used in organic synthesis reactions, especially for the synthesis of compounds with important biological activities.
-It can also be used as a raw material for drug intermediates and pesticide intermediates.
Method:
4-(4-chlorophenyl)pyrimidine-2-thiol can be prepared by the following steps:
1. REACTION: first 4-chlorophenol and sulfur sodium chloride reaction to generate the corresponding 4-chlorophenylthiophenol.
2. Bromination: 4-chlorophenyl thiophenol reacts with phosphorus tribromide to generate 4-(4-bromophenyl) pyrimidine -2-thiol.
3. Substitution: The target product is prepared by substituting the bromine atom in 4-(4-bromophenyl) pyrimidine -2-thiol by a chlorine ion-phenol substitution reaction.
Safety Information:
- 4-(4-chroophenyl) pyrimidine-2-thiol has certain toxicity to human body, and attention should be paid to avoid direct contact with skin, inhalation of gas or accidental ingestion.
-When using or handling the compound, be sure to wear appropriate personal protective equipment, such as gloves and goggles.
-When storing and handling this compound, follow safe operating guidelines to ensure that it is kept away from ignition and flammable materials.
-As an organic compound, it should be operated in a well-ventilated place to avoid the accumulation of harmful gases.
Nature:
-Appearance: 4-(4-chlorophenyl)pyrimidine-2-thiol is a white crystalline solid.
-Solubility: It is soluble in most organic solvents, such as methanol, ethanol and dichloromethane, but difficult to dissolve in water.
-Stability: The compound is relatively stable under regular environmental conditions.
Use:
- 4-(4-chlorophenyl)pyrimidine-2-thiol is widely used in organic synthesis reactions, especially for the synthesis of compounds with important biological activities.
-It can also be used as a raw material for drug intermediates and pesticide intermediates.
Method:
4-(4-chlorophenyl)pyrimidine-2-thiol can be prepared by the following steps:
1. REACTION: first 4-chlorophenol and sulfur sodium chloride reaction to generate the corresponding 4-chlorophenylthiophenol.
2. Bromination: 4-chlorophenyl thiophenol reacts with phosphorus tribromide to generate 4-(4-bromophenyl) pyrimidine -2-thiol.
3. Substitution: The target product is prepared by substituting the bromine atom in 4-(4-bromophenyl) pyrimidine -2-thiol by a chlorine ion-phenol substitution reaction.
Safety Information:
- 4-(4-chroophenyl) pyrimidine-2-thiol has certain toxicity to human body, and attention should be paid to avoid direct contact with skin, inhalation of gas or accidental ingestion.
-When using or handling the compound, be sure to wear appropriate personal protective equipment, such as gloves and goggles.
-When storing and handling this compound, follow safe operating guidelines to ensure that it is kept away from ignition and flammable materials.
-As an organic compound, it should be operated in a well-ventilated place to avoid the accumulation of harmful gases.
Last Update：2024-04-09 02:00:43
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