177966-58-4
fmoc-3,4-dichloro-D-phenylalanine
CAS: 177966-58-4
Molecular Formula: C24H19Cl2NO4
177966-58-4 - Names and Identifiers
| Name | fmoc-3,4-dichloro-D-phenylalanine |
| Synonyms | RARECHEM BK PT 0120 Fmoc-D-3,4-Dichlorophe FMOC-D-3,4-Dichlorophe Fmoc-D-3,4-Dichlorophenylalanine fmoc-3,4-dichloro-D-phenylalanine FMOC-3,4-DICHLORO-D-PHENYLALANINE N-ALPHA-FMOC-3,4-DICHLORO-D-PHENYLALANINE fluorenylmethoxycarbonyl-d-3,4-dichlorophenylalanine FMoc-D-Phe(3,4-Cl2)-OH FMoc-3,4-Dichloro-D-Phenylalanine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-3,4-DICHLOROPHENYLALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-3,4-DICHLORO-D-PHENYLALANINE (R)-3-(3,4-DICHLORO-PHENYL)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PROPIONIC ACID |
| CAS | 177966-58-4 |
| InChI | InChI=1/C24H19Cl2NO4/c25-20-10-9-14(11-21(20)26)12-22(23(28)29)27-24(30)31-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-11,19,22H,12-13H2,(H,27,30)(H,28,29)/t22-/m0/s1 |
| InChIKey | QNVHCYWPXIGFGN-JOCHJYFZSA-N |
177966-58-4 - Physico-chemical Properties
| Molecular Formula | C24H19Cl2NO4 |
| Molar Mass | 456.32 |
| Density | 1.394±0.06 g/cm3(Predicted) |
| Melting Point | 122°C |
| Boling Point | 661.7±55.0 °C(Predicted) |
| Specific Rotation(α) | 30 º (c=1,DMF) |
| Flash Point | 354°C |
| Vapor Presure | 2.07E-18mmHg at 25°C |
| BRN | 9016647 |
| pKa | 3?+-.0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.641 |
| MDL | MFCD00273472 |
177966-58-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
177966-58-4 - Introduction
fmoc-3,4-dichloro-D-phenylalanine(Fmoc-D-3) is an amino acid derivative. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-molecular formula: C17H15Cl2NO2
-Molecular weight: 346.21g/mol
Use:
fmoc-3,4-dichloro-D-phenylalanine is commonly used in solid-phase synthesis as one of the building blocks of peptides and proteins. It can be used to synthesize polypeptides of specific sequences to study the structure and function of biomolecules.
Method:
fmoc-3, the preparation of 4-dichloro-D-phenylalanine can be completed by the following steps:
1. Reaction of D-3,4-dichlorophenylalanine with a dipeptide substrate in dichloromethane to produce a fmoc-3,4-dichloro-D-phenylalanine dipeptide ester (Fmoc-D-3).
2., 4-dichloro-D-phenylalanine dipeptide Ester is reacted with Fmoc protecting group fmoc-3 to give fmoc-3,4-dichloro-D-phenylalanine.
Safety Information:
fmoc-3,4-dichloro-D-phenylalanine is relatively safe under general conditions, and the following safety measures should be observed when used in the laboratory:
-Wear appropriate protective gloves, glasses and lab coats to avoid direct contact with skin and eyes.
-Operate in a well-ventilated place to avoid inhaling aerosols or dust.
-avoid contact with strong oxidant or strong acid, alkali and other substances, so as not to cause chemical reaction or dangerous situation.
-Disposal of surplus material shall be carried out in accordance with local chemical waste disposal regulations.
Please note that in order to ensure safety and efficiency, the fmoc-3,4-dichloro-D-phenylalanine should be used in accordance with laboratory safety operations and related specifications.
Nature:
-Appearance: White crystalline solid
-molecular formula: C17H15Cl2NO2
-Molecular weight: 346.21g/mol
Use:
fmoc-3,4-dichloro-D-phenylalanine is commonly used in solid-phase synthesis as one of the building blocks of peptides and proteins. It can be used to synthesize polypeptides of specific sequences to study the structure and function of biomolecules.
Method:
fmoc-3, the preparation of 4-dichloro-D-phenylalanine can be completed by the following steps:
1. Reaction of D-3,4-dichlorophenylalanine with a dipeptide substrate in dichloromethane to produce a fmoc-3,4-dichloro-D-phenylalanine dipeptide ester (Fmoc-D-3).
2., 4-dichloro-D-phenylalanine dipeptide Ester is reacted with Fmoc protecting group fmoc-3 to give fmoc-3,4-dichloro-D-phenylalanine.
Safety Information:
fmoc-3,4-dichloro-D-phenylalanine is relatively safe under general conditions, and the following safety measures should be observed when used in the laboratory:
-Wear appropriate protective gloves, glasses and lab coats to avoid direct contact with skin and eyes.
-Operate in a well-ventilated place to avoid inhaling aerosols or dust.
-avoid contact with strong oxidant or strong acid, alkali and other substances, so as not to cause chemical reaction or dangerous situation.
-Disposal of surplus material shall be carried out in accordance with local chemical waste disposal regulations.
Please note that in order to ensure safety and efficiency, the fmoc-3,4-dichloro-D-phenylalanine should be used in accordance with laboratory safety operations and related specifications.
Last Update：2024-04-10 22:29:15
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