17908-57-5
β-Melanocyte Stimulating Hormone human
CAS: 17908-57-5
Molecular Formula: C118H174N34O35S
17908-57-5 - Names and Identifiers
17908-57-5 - Physico-chemical Properties
| Molecular Formula | C118H174N34O35S |
| Molar Mass | 2660.92 |
| Density | 1.54±0.1 g/cm3(Predicted) |
| Storage Condition | −20°C |
| MDL | MFCD00167548 |
| In vitro study | β-Melanocyte Stimulating Hormone (MSH), human (β-MSH) has high affinity at both human MC4-R transfected into CHO cells (K i =11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (K i =5.0±0.4 nM). |
17908-57-5 - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
17908-57-5 - Reference Information
| overview | melanogenic hormone is a peptide hormone secreted by the adenohypophysis. Its molecular structure is similar to that of adrenocorticotropic hormone. This hormone can act on melanocytes located in the skin, hair, etc., activate tyrosinase in the cells, promote the conversion of tyrosine into melanin, thereby deepening the color of the skin and hair. In addition, MSH has the effect of aggravating the symptoms of tremor paralysis. The melanotropin releasing factor and melanotropin releasing inhibitory factor secreted by the hypothalamus jointly regulate the secretion of MSH by the adenohypophysis, but in normal times, the hypothalamus mainly releases melanotropin releasing inhibitory factor, so the adenohypophysis does not secrete MSH at rest. |
| Biological activity | β-Melanocyte Stimulating Hormone (MSH), human, is a 22 peptide, an endogenous melanocortin-4 receptor (melanocortin-4 receptor; MC4-R) agonist. |
| target | Melanocortin-4 receptor (MC4-R) |
| in vitro study | β-Melanocyte Stimulating Hormone (MSH), human (β-MSH) has high affinity at both human MC4-R transfected into CHO cells (K I = 11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (K I = 5.0±0.4 nM). |
Last Update：2024-04-09 21:54:55
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