18212-21-0
4-methyl-1,2,3-thiadiazole-5-carboxylic acid
CAS: 18212-21-0
Molecular Formula: C4H4N2O2S
18212-21-0 - Names and Identifiers
18212-21-0 - Physico-chemical Properties
| Molecular Formula | C4H4N2O2S |
| Molar Mass | 144.15 |
| Density | 1.530±0.06 g/cm3(Predicted) |
| Melting Point | 169-173 °C (D) |
| Boling Point | 315.2±34.0 °C(Predicted) |
| Flash Point | 144.4°C |
| Solubility | Aqueous Base (Slightly), DMSO |
| Vapor Presure | 0.000188mmHg at 25°C |
| Appearance | Powder |
| Color | Off-White |
| pKa | 1.33±0.37(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00173830 |
18212-21-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Class | IRRITANT |
18212-21-0 - Introduction
4-methyl-1,2, acid is an organic compound with the chemical formula C6H5N3O2S, and the structure contains thiadiazole and carboxylic acid functional groups.
Nature:
-Appearance: 4-methyl-1,2, acrylic is a white crystalline powder.
-Melting point: about 160-165 ° C.
-Solubility: Soluble in common organic solvents such as alcohol, ketone, ether, slightly soluble in water.
Use:
-As a pharmaceutical intermediate: 4-methyl-1,2, acid is an important thiadiazole compound, which has a wide range of applications in pharmaceutical research and synthesis. It can be used to synthesize a variety of biologically active thiadiazole derivatives, such as antibacterial drugs, anti-tumor drugs, etc.
Method:
4-methyl-1,2, acid can be prepared in a variety of ways, commonly used methods include:
-reaction of thiadiazole and methyl halide: reacting thiadiazole with methyl halide (such as methyl iodide) under alkaline conditions to generate 4-methyl-1,2,3-thiadiazole, then through the oxidation reaction, 4-methyl-1,2, phenyl acid was obtained.
-reaction of thiadiazole and carbonic acid: reaction of thiadiazole with carbonic acid to generate the corresponding carboxylic acid.
-Synthesis of thiadiazole derivatives of existing compounds: Through the thiadiazolylation reaction of specific groups in existing compounds, 4-methyl-1,2, 5-oxadiazole acid is obtained.
Safety Information:
- 4-methyl-1,2, and acid are chemicals that need to be handled in accordance with safety procedures.
-It may be irritating and damaging to the skin, eyes and respiratory system, avoid contact and inhalation.
-in storage and transportation should prevent contact with oxidants, strong acid, strong alkali, avoid fire and high temperature.
It should be noted that in the specific preparation and use process, it is also necessary to refer to relevant literature and laboratory practices to ensure safety and efficiency.
Nature:
-Appearance: 4-methyl-1,2, acrylic is a white crystalline powder.
-Melting point: about 160-165 ° C.
-Solubility: Soluble in common organic solvents such as alcohol, ketone, ether, slightly soluble in water.
Use:
-As a pharmaceutical intermediate: 4-methyl-1,2, acid is an important thiadiazole compound, which has a wide range of applications in pharmaceutical research and synthesis. It can be used to synthesize a variety of biologically active thiadiazole derivatives, such as antibacterial drugs, anti-tumor drugs, etc.
Method:
4-methyl-1,2, acid can be prepared in a variety of ways, commonly used methods include:
-reaction of thiadiazole and methyl halide: reacting thiadiazole with methyl halide (such as methyl iodide) under alkaline conditions to generate 4-methyl-1,2,3-thiadiazole, then through the oxidation reaction, 4-methyl-1,2, phenyl acid was obtained.
-reaction of thiadiazole and carbonic acid: reaction of thiadiazole with carbonic acid to generate the corresponding carboxylic acid.
-Synthesis of thiadiazole derivatives of existing compounds: Through the thiadiazolylation reaction of specific groups in existing compounds, 4-methyl-1,2, 5-oxadiazole acid is obtained.
Safety Information:
- 4-methyl-1,2, and acid are chemicals that need to be handled in accordance with safety procedures.
-It may be irritating and damaging to the skin, eyes and respiratory system, avoid contact and inhalation.
-in storage and transportation should prevent contact with oxidants, strong acid, strong alkali, avoid fire and high temperature.
It should be noted that in the specific preparation and use process, it is also necessary to refer to relevant literature and laboratory practices to ensure safety and efficiency.
Last Update：2024-04-09 02:00:43
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