186320-06-9
(S)-N-Fmoc-3-Thienylalanine
CAS: 186320-06-9
Molecular Formula: C22H19NO4S
186320-06-9 - Names and Identifiers
| Name | (S)-N-Fmoc-3-Thienylalanine |
| Synonyms | FMOC-L-3-THI Fmoc-3-L-Ala(3-thienyl)-OH Fmoc-L-3-(3-Thienyl)alanine (S)-N-Fmoc-3-Thienylalanine Fmoc-3-(3-Thienyl)-L-alanine (9H-Fluoren-9-yl)MethOxy]Carbonyl L-3-Thienylalanine (αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-thiophenepropanoic acid (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(3-thiophenyl)propanoate (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(thiophen-3-yl)propanoic acid |
| CAS | 186320-06-9 |
| InChI | InChI=1/C22H19NO4S/c24-21(25)20(11-14-9-10-28-13-14)23-22(26)27-12-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-10,13,19-20H,11-12H2,(H,23,26)(H,24,25)/p-1/t20-/m0/s1 |
186320-06-9 - Physico-chemical Properties
| Molecular Formula | C22H19NO4S |
| Molar Mass | 393.46 |
| Density | 1.2174 (rough estimate) |
| Melting Point | 188.4 °C |
| Boling Point | 626.3±55.0 °C(Predicted) |
| Flash Point | 332.6°C |
| Vapor Presure | 1.5E-16mmHg at 25°C |
| Appearance | White powder |
| pKa | 3.74±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5060 (estimate) |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ WGK Germany:3 |
186320-06-9 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
186320-06-9 - Introduction
(S)-N-Fmoc-3-Thienylalanine is a chemical substance with the following characteristics:
Nature:
1. Appearance: White or almost white crystalline powder.
2. Molecular formula: C26H20N2O4S.
3. Molecular weight: 456.51g/mol.
4. Melting point: 157-160 degrees Celsius.
Use:
1. (S)-N-Fmoc-3-Thienylalanine is an amino acid derivative widely used in the fields of biochemistry and organic synthesis. It can be used in the synthesis of polypeptides and proteins, usually as a protecting group and a reactive functional group.
2. It can also be used to synthesize biologically active compounds, such as drugs, enzyme inhibitors, etc.
Method: The synthesis of
(S)-N-Fmoc-3-Thienylalanine is mainly divided into two steps:
1. First, 3-thiophenepropionic acid reacts with FMOC-L-o-benzoic anhydride to generate FMOC-L-3-thiophenepropionic acid.
2. The carboxyl group in FMOC-L-3-thiophenepropionic acid is then reacted with an amino acid by reaction with dimethylaminopyrimidine (DMAP) and an activating agent such as diisopropyl carbodiimide to form (S)-N-Fmoc-3-Thienylalanine.
Safety Information:
(S)-The N-Fmoc-3-Thienylalanine is stable under normal conditions of use. However, during handling and storage, the following safety precautions need to be taken into consideration:
1. Avoid contact with skin and eyes, such as accidental contact should immediately rinse with plenty of water.
2. When using the compound, use appropriate personal protective equipment, such as laboratory gloves, protective glasses and protective clothing.
3. It is strictly forbidden to inhale powder or aerosol, and it is necessary to maintain a well-ventilated working environment.
4. Storage should avoid high temperature and direct sunlight, keep in a dry and cool place, and store separately from oxidants and acids.
Nature:
1. Appearance: White or almost white crystalline powder.
2. Molecular formula: C26H20N2O4S.
3. Molecular weight: 456.51g/mol.
4. Melting point: 157-160 degrees Celsius.
Use:
1. (S)-N-Fmoc-3-Thienylalanine is an amino acid derivative widely used in the fields of biochemistry and organic synthesis. It can be used in the synthesis of polypeptides and proteins, usually as a protecting group and a reactive functional group.
2. It can also be used to synthesize biologically active compounds, such as drugs, enzyme inhibitors, etc.
Method: The synthesis of
(S)-N-Fmoc-3-Thienylalanine is mainly divided into two steps:
1. First, 3-thiophenepropionic acid reacts with FMOC-L-o-benzoic anhydride to generate FMOC-L-3-thiophenepropionic acid.
2. The carboxyl group in FMOC-L-3-thiophenepropionic acid is then reacted with an amino acid by reaction with dimethylaminopyrimidine (DMAP) and an activating agent such as diisopropyl carbodiimide to form (S)-N-Fmoc-3-Thienylalanine.
Safety Information:
(S)-The N-Fmoc-3-Thienylalanine is stable under normal conditions of use. However, during handling and storage, the following safety precautions need to be taken into consideration:
1. Avoid contact with skin and eyes, such as accidental contact should immediately rinse with plenty of water.
2. When using the compound, use appropriate personal protective equipment, such as laboratory gloves, protective glasses and protective clothing.
3. It is strictly forbidden to inhale powder or aerosol, and it is necessary to maintain a well-ventilated working environment.
4. Storage should avoid high temperature and direct sunlight, keep in a dry and cool place, and store separately from oxidants and acids.
Last Update：2024-04-09 21:01:54
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CAS: 186320-06-9
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