1875-98-3
4-Hydroxymethylthiazole
CAS: 1875-98-3;7036-04-6
Molecular Formula: C4H5NOS
1875-98-3 - Names and Identifiers
| Name | 4-Hydroxymethylthiazole |
| Synonyms | THIAZOLE-4-METHANOL 4-Hydroxymethylthiaz 4-Hydroxymethylthiazole 4-HYDROXYMETHYLTHIAZOLE 4-Hydroxymethylthiazloe 1,3-THIAZOL-4-YLMETHANOL 1,3-thiazol-4-ylmethanol 4-(Hydroxymethyl)-1,3-thiazole |
| CAS | 1875-98-3 7036-04-6 |
| InChI | InChI=1/C4H5NOS/c6-1-4-2-7-3-5-4/h2-3,6H,1H2 |
1875-98-3 - Physico-chemical Properties
| Molecular Formula | C4H5NOS |
| Molar Mass | 115.15 |
| Density | 1.339±0.06 g/cm3(Predicted) |
| Melting Point | 112-114 °C(Solv: ethyl ether (60-29-7); ethanol (64-17-5)) |
| Boling Point | 85-90/0.5mm |
| Flash Point | 104.1°C |
| Vapor Presure | 0.0128mmHg at 25°C |
| pKa | 13.21±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.594 |
1875-98-3 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| Hazard Note | Irritant |
1875-98-3 - Introduction
4-Hydroxymethylthiazole is an organic compound with the chemical formula C4H5NO2S, which is a light yellow solid.
Nature:
1. 4-Hydroxymethylthiazole is solid at normal temperature and pressure, with a melting point of 180-184 ° C.
2. It can be dissolved in water, ethanol and Ether solvents, slightly dissolved in acetone and chloroform.
3. 4-Hydroxymethylthiazole has certain toxicity and can corrode skin and eyes, so safety measures need to be taken during operation.
Use:
1. 4-Hydroxymethylthiazole is an important chemical intermediate, which can be used to synthesize organic compounds such as drugs and dyes.
2. It is commonly used in the preparation of drugs to inhibit HIV and AIDS virus.
Method:
4-Hydroxymethylthiazole has many synthesis methods, and the commonly used methods are:
1. By reacting sodium thiocyanate with formaldehyde under alkaline conditions, 1-mercapto formaldehyde is generated, and then 4-Hydroxymethylthiazole is obtained by oxidation.
2.1H-thiazol-4-one can be generated by the reaction of maleic anhydride and thiourea under alkaline conditions, and then 4-Hydroxymethylthiazole can be obtained by reduction reaction.
Safety Information:
1. 4-Hydroxymethylthiazole has certain toxicity. Appropriate protective equipment should be worn when using it to avoid contact with skin and eyes.
2. In the operation should pay attention to prevent the inhalation of dust or gas, maintain good ventilation conditions.
3. If taken by mistake or inhaled by mistake, seek medical attention immediately and bring the packaging and label of the compound.
Nature:
1. 4-Hydroxymethylthiazole is solid at normal temperature and pressure, with a melting point of 180-184 ° C.
2. It can be dissolved in water, ethanol and Ether solvents, slightly dissolved in acetone and chloroform.
3. 4-Hydroxymethylthiazole has certain toxicity and can corrode skin and eyes, so safety measures need to be taken during operation.
Use:
1. 4-Hydroxymethylthiazole is an important chemical intermediate, which can be used to synthesize organic compounds such as drugs and dyes.
2. It is commonly used in the preparation of drugs to inhibit HIV and AIDS virus.
Method:
4-Hydroxymethylthiazole has many synthesis methods, and the commonly used methods are:
1. By reacting sodium thiocyanate with formaldehyde under alkaline conditions, 1-mercapto formaldehyde is generated, and then 4-Hydroxymethylthiazole is obtained by oxidation.
2.1H-thiazol-4-one can be generated by the reaction of maleic anhydride and thiourea under alkaline conditions, and then 4-Hydroxymethylthiazole can be obtained by reduction reaction.
Safety Information:
1. 4-Hydroxymethylthiazole has certain toxicity. Appropriate protective equipment should be worn when using it to avoid contact with skin and eyes.
2. In the operation should pay attention to prevent the inhalation of dust or gas, maintain good ventilation conditions.
3. If taken by mistake or inhaled by mistake, seek medical attention immediately and bring the packaging and label of the compound.
Last Update：2024-04-09 02:00:44
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-(Hydroxymethyl)thiazole Request for quotationCAS: 7036-04-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 4-(Hydroxymethyl)thiazole Visit Supplier Webpage Request for quotationCAS: 7036-04-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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View History
1875-98-3
Extracts of Veratrum aldehyde
P.R.146
CyprisateCI
Disperse Red 152
Acide thioglycolique
Samarium phosphate
NSC 170950
2-NAPHTHALENEACETONITRILE
Cinnamic acid, phenylethyl ester
Extracts of Veratrum aldehyde
P.R.146
CyprisateCI
Disperse Red 152
Acide thioglycolique
Samarium phosphate
NSC 170950
2-NAPHTHALENEACETONITRILE
Cinnamic acid, phenylethyl ester