189278-27-1
2-bromo-6-(trifluoromethyl)pyridine
CAS: 189278-27-1
Molecular Formula: C6H3BrF3N
189278-27-1 - Names and Identifiers
| Name | 2-bromo-6-(trifluoromethyl)pyridine |
| Synonyms | 2-Bromo-6-(t 2-Bromo-6-trifluoronethylpyridine 2-Bromo-6-trifluoromethylpyridine 2-TRIFLUOROMETHYL-6-BROMOPYRIDINE 2-bromo-6-(trifluoromethyl)pyridine 2-Bromo-6-(trifluoromethyl)pyridine 2-BROMO-6-(TRIFLUOROMETHYL)PYRIDINE 6-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE 2-Bromo-6-(trifuluoromethyl)pyridine 6-Bromo-alpha,alpha,alpha-trifluoro-2-picoline |
| CAS | 189278-27-1 |
| InChI | InChI=1/C6H3BrF3N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H |
| InChIKey | DOWNSQADAFSSAR-UHFFFAOYSA-N |
189278-27-1 - Physico-chemical Properties
| Molecular Formula | C6H3BrF3N |
| Molar Mass | 225.99 |
| Density | 1.707±0.06 g/cm3(Predicted) |
| Melting Point | 48-52°C |
| Boling Point | 78-79°C 14mm |
| Flash Point | 78-79°C/14mm |
| Vapor Presure | 1.93mmHg at 25°C |
| pKa | -3.89±0.12(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.471 |
| MDL | MFCD00153087 |
189278-27-1 - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
| Packing Group | Ⅲ |
189278-27-1 - Reference Information
| Application | 2-bromo-6-trifluoromethylpyridine is a pyridine compound. Pyridine is the most widely used nitrogen-containing heterocyclic ring. Its chemical properties are very active and are widely used in medicine, pesticides, dyes, rubber and other fields. |
| preparation | preparation of 2-hydrazinyl -6-trifluoromethylpyridine: add 14.5g of 40% hydrazine hydrate and 10ml of isopropanol in a 100ml single-mouth bottle, slowly drop 7g 2-chloro -6-trifluoromethylpyridine into the mixed solution at room temperature, after dropping, the temperature is raised until reflux is stirred for 1h. After cooling, the reaction solution is poured into water, extracted with ethyl acetate, organic phases are combined, anhydrous sodium sulfate is dried, and the solvent is evaporated to obtain 6.5g of white solid. Preparation of 2-bromo-6-trifluoromethylpyridine: 5g2-hydrazin-6-trifluoromethylpyridine and 50ml chloroform were added to a 100ml three-mouth bottle, 2.89ml bromine was added dropwise at room temperature, and then rose to reflux and stirred for 1h after dripping. After cooling, pour the reaction solution into water, add 10ml of saturated sodium thiosulfate solution, adjust pH = 8 with saturated sodium carbonate solution, extract with ethyl acetate, combine organic phases, dry with anhydrous sodium sulfate, and evaporate the solvent to obtain 5.57g of white solid. |
Last Update：2024-04-10 22:29:15
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