191595-63-8
2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINICACID
CAS: 191595-63-8
Molecular Formula: C7H4F3NO3
191595-63-8 - Names and Identifiers
191595-63-8 - Physico-chemical Properties
| Molecular Formula | C7H4F3NO3 |
| Molar Mass | 207.11 |
| Density | 1.629g/cm3 |
| Melting Point | 165-167°C |
| Boling Point | 372.484°C at 760 mmHg |
| Flash Point | 179.072°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.512 |
191595-63-8 - Reference Information
| uses | 2-hydroxy-6-trifluoromethylnicotinic acid is an important pharmaceutical intermediate, mainly used in medicine, food, feed and other fields, can also be used as intermediates of fungicides. |
| preparation | step 1, in a three-necked flask of 250ml, 10g of 2-hydroxy-6-trifluoromethylnicotinonitrile, 16.2g of phosphorus pentachloride and 40g of phosphorus oxychloride were added, heated to 100 ° C., followed by HPLC. The reaction lasted for 6 hours, it was added to ice water, extracted with dichloromethane, and the organic phase was dried, suction filtered and rotary dried to obtain 9.2g of solid 2-chloro-6-trifluoromethylnicotinonitrile with a purity of 93%. MS(EI)M 206(80.61)(M 2) 208(25.32). Step 2: 1g of 2-chloro-6-trifluoromethylnicotinonitrile and 1.9g of 40% sulfuric acid prepared in step 1 were added to a 50ml single-necked flask, oil bath heating 100 ℃, with HPLC tracking, reaction 4 days, raw material reaction, cooling, adding ice water, ethyl acetate extraction, spin dry, 0.88g of 2-hydroxy-6-trifluoromethylnicotinic acid were obtained as a yellow solid with a purity of 95.6%. MS(EI)M 207(37.64). |
Last Update：2024-04-09 21:04:16
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