192189-13-2
1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-diMethylethyl ester
CAS: 192189-13-2
Molecular Formula: C13H13FINO2
192189-13-2 - Names and Identifiers
192189-13-2 - Physico-chemical Properties
| Molecular Formula | C13H13FINO2 |
| Molar Mass | 361.15 |
| Storage Condition | 2-8 ℃, dark |
| MDL | MFCD13183351 |
192189-13-2 - Introduction
1H-Indole-1-carboxylic acid, 5-fluoroo-3-iodo-, 1,1-dimethylethyl ester(3-iodo-5-fluoro-N-Boc indole) is an organic compound. Its chemical formula is C16H15FINO2 and its molecular weight is 383.20g/mol. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester as a white to yellowish solid.
-Melting point: about 78-82 ℃.
-Solubility: It is soluble in most organic solvents, such as methanol, dimethyl sulfoxide, ethanol and dichloromethane.
Use:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester is an important organic synthesis intermediate. It can be used to synthesize various indole compounds with pharmaceutical activity.
-In the field of medicine, indole compounds are widely used in the synthesis of anticancer, antiviral and antibacterial drugs.
Method:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester can be prepared by iodination and fluorination reactions. The specific synthetic route can be adjusted as needed. Here is a possible preparation method:
1. Reacting the N-Boc protected indole with iodine in an organic solvent to generate 3-iodo-N-Boc indole.
2. React 3-iodo-N-Boc indole with fluorination reagent to generate the target product 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester.
Safety Information:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester has limited toxicity and hazard data, so appropriate safety measures should be taken when using it.
-It may cause irritation to the eyes, skin and respiratory tract, so avoid direct exposure when in contact and ensure good ventilation.
-Wear appropriate personal protective equipment such as laboratory gloves, goggles, etc. during operation.
-For a detailed assessment of toxicity and Hazard, reference should also be made to the relevant safety data sheets and operating manuals.
Nature:
-Appearance: 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester as a white to yellowish solid.
-Melting point: about 78-82 ℃.
-Solubility: It is soluble in most organic solvents, such as methanol, dimethyl sulfoxide, ethanol and dichloromethane.
Use:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester is an important organic synthesis intermediate. It can be used to synthesize various indole compounds with pharmaceutical activity.
-In the field of medicine, indole compounds are widely used in the synthesis of anticancer, antiviral and antibacterial drugs.
Method:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester can be prepared by iodination and fluorination reactions. The specific synthetic route can be adjusted as needed. Here is a possible preparation method:
1. Reacting the N-Boc protected indole with iodine in an organic solvent to generate 3-iodo-N-Boc indole.
2. React 3-iodo-N-Boc indole with fluorination reagent to generate the target product 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester.
Safety Information:
- 1H-Indole-1-carboxylic acid, 5-fluoro-3-iodo-, 1,1-dimethylethyl ester has limited toxicity and hazard data, so appropriate safety measures should be taken when using it.
-It may cause irritation to the eyes, skin and respiratory tract, so avoid direct exposure when in contact and ensure good ventilation.
-Wear appropriate personal protective equipment such as laboratory gloves, goggles, etc. during operation.
-For a detailed assessment of toxicity and Hazard, reference should also be made to the relevant safety data sheets and operating manuals.
Last Update：2024-04-09 20:49:11
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