19473-49-5
L-Glutamic acid monopotassium salt
CAS: 19473-49-5
Molecular Formula: C5H10KNO4
19473-49-5 - Names and Identifiers
19473-49-5 - Physico-chemical Properties
| Molecular Formula | C5H10KNO4 |
| Molar Mass | 187.24 |
| Appearance | powder |
| Color | white |
| Physical and Chemical Properties | A chemically white, essentially odorless and flowable crystalline powder. Have a special taste. It's hygroscopic. Easily soluble in water, hardly soluble in ethanol. The PH value of 2% aqueous solution is 6.7~7.3. |
| Use | Uses Flavoring agent, salt substitute. According to FAO/WHO regulations, it can be used for broth and soup in convenience foods, and the maximum allowable dosage is 10 g/kg (used alone or combined with other glutamic acid and its salts). EEC is used for sodium-free condiments. |
19473-49-5 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | MA1450000 |
19473-49-5 - Upstream Downstream Industry
| Raw Materials | Potassium carbonate Potassium hydrogen 2-oxoglutarate |
19473-49-5 - Uses and synthesis methods
Potassium glutamate
Potassium glutamate is a drug for liver coma, and its pharmacological effect is the same as "sodium glutamate". It is used to treat hepatic encephalopathy caused by increased blood ammonia. It is often used in a 1:2 ratio match with sodium glutamate.
It has always been believed that potassium glutamate uses ammonia to synthesize glutamine to reduce blood ammonia, which is helpful for the recovery of hepatic encephalopathy. In the past 10 years, it has been repeatedly rejected. It is believed that blood ammonia level is not directly related to hepatic coma. This product is no longer used as a routine treatment for hepatic coma.
usage and dosage
drop g each time to coma the liver: drop 11.5g (2 injections of 5.75/20ml) each time, dilute it with 750-1000ml of 5% glucose solution or 250-500ml of 10% glucose solution, and finish the drop within 1-4 hours. if the drop is too fast, salivation, flushing, vomiting, etc. can be caused. If necessary, the drug can be repeated after 8~12 hours, and the daily dose should not exceed 23g. For acidemia: the dosage is determined according to the condition.
identification test
take 1/30 sample solution lml, add indantrione hydrated test solution (TS-250) and sodium acetate 100mg. Heat on a boiling water bath for 10min to produce a thick violet color.
take 10ml of 10% sample solution and add 5.6ml of lmol/L hydrochloric acid. Stent, should produce white glutamic acid crystal precipitation. After shaking and mixing, add lmol/L hydrochloric acid to 6ml, and dissolve glutamic acid after stirring.
10% the potassium salt test (IT-27) of the sample solution is positive.
content analysis
accurately weigh the sample 250mg and dissolve in 100ml glacial acetic acid. If several drops of water are added to glacial acetic acid first, the dissolution of the sample can be accelerated. The glacial acetic acid solution was titrated with 0.1mol/L perchloric acid, and the end point was determined by potential difference. 0.1mol/L perchloric acid per Ml is equivalent to L-glutamic acid monopotassium (C5H8KNO4?H2O)10.16mg.
Toxicity
ADI does not make special regulations (FAO/WHO,2001). GRAS(FDA,& sect;182.1516,2000).
LD50 4500mg/kg (mouse, oral)
according to EEC-HACSG regulations, it shall not be used for infants within 12 weeks.
Production method
L-glutamic acid obtained by fermentation method is neutralized, decolorized and crystallized with potassium hydroxide or potassium carbonate.
Last Update：2024-04-09 01:59:51
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Mobile: +86-18621343501
QQ: 2881950922
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View History
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Raw Materials for 19473-49-5